Browsing Synthesis and Solid State Pharmaceutical Centre by Subject "glass transition"

Now showing items 1-2 of 2

The effect of cooling on the degree of crystallinity,solid-state properties, and dissolution rate of multi-component hot-melt extruded solid dispersions

Hurley, Dean; Davis, Mark; Walker, Gavin M.; Lyons, John G.; Higginbotham, Clement L. (MDPI, 2020)

The effect of cooling on the degree of crystallinity, solid-state and dissolution properties of multi-component hot-melt extruded solid dispersions [SD] is of great interest for the successful formulation of amorphous SDs ...
Investigation of the capacity of low glass transition temperature excipients to minimise amorphisation of sulfadimidine on co-milling

Curtin, Vincent; Amharar, Youness; Hu, Yun; Erxleben, Andrea; McArdle, Patrick; Caron, Vincent; Tajber, Lidia; Corrigan, Owen I; Healy, Anne Marie (American Chemical Society, 2013)

The coprocessing of active pharmaceutical ingredient (API) with an excipient which has a high glass transition temperature (Tg) is a recognized strategy to stabilize the amorphous form of a drug. This work investigates ...

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