Browsing Synthesis and Solid State Pharmaceutical Centre by Author "Long, Barry"

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Controlling polymorphism of carbamazepine nanoparticles in a continuous supercritical-CO2-assisted spray drying process

Long, Barry; Walker, Gavin M.; Ryan, Kevin M.; Padrela, Luis (American Chemical Society, 2019)

Controlling polymorphism in the transition from batch to continuous crystallization represents a major obstacle for the pharmaceutical industry. This work demonstrates a novel methodology to control the polymorphism of ...
Investigating process variables and additive selection to optimize polymorphic control of carbamazepine in a CO2 antisolvent crystallization process

Long, Barry; Ryan, Kevin M.; Padrela, Luis (American Chemical Society, 2020)

Supercritical CO2 antisolvent crystallization typically promotes the formation of metastable polymorphic forms of pharmaceutical drugs. However, using this technological approach in combination with the use of distinct ...

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