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Browsing Synthesis and Solid State Pharmaceutical Centre by Title

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  • Keshavarz, Leila; Pishnamazi, Mahboubeh; Khandavilli, U.B. Rao; Shirazian, Saeed; Collins, Maurice N.; Walker, Gavin M.; Frawley, Patrick J. (Elsevier, 2021)
    Paracetamol crystals often exhibit poor compressibility properties, which results in capping issues. The Particle Size Distribution (PSD) of paracetamol was engineered to improve the compressibility of paracetamol crystals. ...
  • Svärd, Michael; Valavi, Masood; Khamar, Dikshitkumar; Kuhs, Manuel; Rasmuson, Åke C. (Elsevier, 2016)
    Melting temperatures and enthalpies of fusion have been determined by differential scanning calorimetry (DSC) for 2 polymorphs of the drug tolbutamide: FIH and FV. Heat capacities have been determined by temperature-modulated ...
  • Svärd, Michael; Nordström, Fredrik; Jasnobulka, Tanja; Rasmuson, Åke C. (American Chemical Society, 2010)
    The polymorphism of m-aminobenzoic acid has been investigated, Two polymorphs have been identified and characterized by X-ray powder diffraction (XRPD). Fourier transform IR (FTIR), microscopy, and thermal analysis. The ...
  • Svärd, Michael; Nordström, Fredrik; Hoffman, Eva-Maria; Aziz, Baroz; Rasmuson, Åke C. (Royal Society of Chemistry, 2013)
    In this work, the thermodynamic interrelationship of the two known polymorphs of p-aminobenzoic acid has been explored, and primary nucleation in different organic solvents investigated. The solubility of both polymorphs ...
  • Watterson, Samuel; Hudson, Sarah P.; Svärd, Michael; Rasmuson, Åke C. (Elsevier, 2014)
    Calorimetric data on the melting of 1-methylethyl 2-[4-(4-chlorobenzoyl)-phenoxy]-2-methylpropanoate (fenofibrate) and the heat capacity of the solid and the melt have been determined, from which the Gibbs energy, enthalpy ...
  • Kuhs, Manuel; Svärd, Michael; Rasmuson, Åke C. (Elsevier, 2013)
    The solubility of fenoxycarb has been determined between 278 and 318 K in several organic solvents. The solid phase at equilibrium and some indication of polymorphism has been properly examined by powder XRD, DSC, Raman ...
  • Mealey, Donal; Svärd, Michael; Rasmuson, Åke C. (Elsevier, 2014)
    The solid-liquid solubility of the thermodynamically stable form I of the drug risperidone has been determined by a gravimetric method in nine pure organic solvents in the temperature range 278.15-323.15 K. The melting ...
  • Croker, Denise M.; Foreman, Michael E.; Hogan, Bridget N.; Maguire, Nuala M.; Elcoate, Curtis J.; Hodnett, Benjamin K.; Maguire, Anita R.; Rasmuson, Åke C.; Lawrence, Simon E. (American Chemical Society, 2012)
    A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with ...
  • Frawley, Patrick J.; Hayes, Sarah; Hodnett, Benjamin K.; O'Halloran, Jon (University of Limerick, 2014)
    Pharmaceutical manufacturing contributes vitally to Ireland’s economy: it employs over 25,000 individuals directly and 24,500 indirectly, and produces over 50% of all exports, making Ireland the second-largest pharmaceutical ...
  • Padrela, Luis; Zeglinski, Jacek; Ryan, Kevin M. (American Chemical Society, 2018)
    Molecular tautomerism has been reported to play an important role in the crystallization of active pharmaceutical ingredients, particularly in the formation of pharmaceutical cocrystals and salts. In this work, by combining ...
  • Culebras, Mario; Barrett, Anthony; Pishnamazi, Mahboubeh; Walker, Gavin M.; Collins, Maurice N. (American Chemical Society, 2021)
    Wood (cellulose and lignin)-based hydrogels were successfully produced as platforms for drug-release systems. Viscoelastic and cross-linking behaviors of precursor solutions were tuned to produce highly porous hydrogel ...

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