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Browsing Graduate Entry Medical School by Title

Now showing items 110-129 of 577

Defining the mesentery as a new organ and what this means for understanding its roles in digestive disorders

O'Leary, Peter D.; Coffey, Calvin J. (Taylor and Francis, 2017)

Categorisation of structures into tissues, organs and systems is arbitrary but has considerable utility as it provides a structural hierarchy within which one can more easily investigate and better understand human biology ...
Delirium and depression: inter-relationship and overlap in elderly people

O'Sullivan, Roisin; Inouye, Sharon K.; Meagher, David (Elsevier, 2014)

Delirium and depression are complex neuropsychiatric syndromes that are common in the elderly and associated with a variety of poor healthcare outcomes. Accurate detection is key to providing optimal care for these conditions ...
Delirium diagnosis defined by cluster analysis of symptoms versus diagnosis by DSM and ICD criteria: diagnostic accuracy study

Sepulveda, Esteban; Franco, José G; Trzepacz, Paula T.; Gaviria, Ana M; Meagher, David; Palma, José; Viñuelas, Eva; Grau, Imma; Vilella, Elisabet; de Pablo, Joan (BioMed Central, 2016)

Background: Information on validity and reliability of delirium criteria is necessary for clinicians, researchers, and further developments of DSM or ICD. We compare four DSM and ICD delirium diagnostic criteria versions, ...
Delirium in an adult acute hospital population: predictors, prevalence and detection

Ryan, Daniel James; O'Regan, Niamh A.; Ó Caoimh, Ronán; Clare, Josie; O'Connor, Marie; Leonard, Maeve; McFarland, John; Tighe, Sheila; O'Sullivan, Kathleen; Trzepacz, Paula T.; Meagher, David; Timmons, Suzanne (BMJ Publishing Group, 2013)

Background: To date, delirium prevalence and incidence in acute hospitals has been estimated from pooled findings of studies performed in distinct patient populations. Objective: To determine delirium prevalence ...
Delirium superimposed on dementia: a quantitative and qualitative evaluation of informal caregivers and health care staff experience

Morandi, Alessandro; Lucchi, Elena; Turco, Renato; Morghen, Sara; Guerini, Fabio; Santi, Rossana; Gentile, Simona; Meagher, David; Voyer, Philippe; Fick, Donna Marie; Schmitt, Eva M.; Inouye, Sharon K.; Trabucchi, Marco T.; Bellelli, Giuseppe (Elsevier, 2015)

Objective—Delirium superimposed on dementia (DSD) is common and potentially distressing for patients, caregivers, and health care staff. We quantitatively and qualitatively assessed the experience of informal caregiver and ...
Delivery through perineal body and severed external anal sphincter with an intact vaginal orifice during a precipitous labor: a case report

Irfah Ismail, Khadijah; McDonnell, Brendan; O'Coigligh, Seosamh (Wiley Open Access, 2015)

We present the case of a patient who delivered her baby through the perineal body with an intact vaginal introitus. Damage to the perineal body through its connection to the external anal sphincter can involve the ...
Dementia in older people admitted to hospital: a regional multi-hospital observational study of prevalence, associations and case recognition

Timmons, Suzanne; Manning, Edmond; Barrett, Aoife; Brady, Noeleen M.; Browne, Vanessa; O'Shea, Emma; Molloy, David William; O'Regan, Niamh A.; Trawley, Steven; Cahill, Suzanne; O'Sullivan, Kathleen; Woods, Noel; Meagher, David; Ni Chorcorain, Aoife M.; Linehan, John G. (Oxford University Press, 2015)

Background: previous studies have indicated a prevalence of dementia in older admissions of 42% in a single London teaching hospital, and 21% in four Queensland hospitals. However, there is a lack of published data from ...
Depth-dependent differences in community structure of the human colonic microbiota in health

Lavelle, Aonghus; Lennon, Grainne; Docherty, Neil G.; Balfe, Áine; Mulcahy, Hugh E; Doherty, Glen; O'Donoghue, Diarmuid; Hyland, John M; Shanahan, Fergus; Sheahan, Kieran; Coffey, Calvin J.; Winter, Desmond C.; O'Connell, Ronan P. (Public Library of Science, 2013)

Objective: The aims of this study were to develop techniques for spatial microbial assessment in humans and to establish colonic luminal and mucosal spatial ecology, encompassing longitudinal and cross-sectional axes. Design: ...
The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the medical research council cognitive function and ageing study (MRC CFAS)

Davis, Daniel H.J.; Barnes, Linda E.; Blossom, Stephan; MacLullich, Alasdair M.; Meagher, David; Copeland, John; Matthews, Fiona E.; Brayne, Carol (BioMed Central, 2014)

Background: In the general population, the epidemiological relationships between delirium and adverse outcomes are not well defined. The aims of this study were to: (1) construct an algorithm for the diagnosis of delirium ...
Design and baseline characteristics of the PODOSA (Prevention of Diabetes & Obesity in South Asians) trial: a cluster, randomised lifestyle intervention in Indian and Pakistani adults with impaired glycaemia at high risk of developing type 2 diabetes

Douglas, Anne; Bhopal, Raj S.; Bhopal, Ruby; Forbes, John F.; Gill, Jason M. R.; McKnight, John; Murray, Gordon D.; Sattar, Naveed; Sharma, Anu; Wallia, Sunita; Wild, Sarah H.; Sheikh, Aziz (BMJ Publishing Group, 2013)

To describe the design and baseline population characteristics of an adapted lifestyle intervention trial aimed at reducing weight and increasing physical activity in people of Indian and Pakistani origin at high risk ...
Detecting delirium superimposed on dementia: evaluation of the diagnostic performance of the Richmond agitation and sedation scale

Morandi, Alessandro; Han, Jin H.; Meagher, David; Vasilevskis, Eduard; Cerejeira, Joaquim; Hasemann, Wolfgang; MacLullich, Alasdair M.; Annoni, Giorgio; Trabucchi, Marco T.; Bellelli, Giuseppe (Elsevier, 2016)

Objectives—Delirium disproportionately affects patients with dementia and is associated with adverse outcomes. The diagnosis of delirium superimposed on dementia (DSD), however, can be challenging due to several factors ...
Detection and diagnosis of delirium: a study of the application of computer-assisted technologies

O'Connell, Henry (University of Limerick, 2016)

Delirium is a common, severe and life threatening neuropsychiatric disorder. Encountered in all healthcare settings, delirium affects approximately one in five general hospital inpatients (Ryan et al., 2013, Siddiqi et ...
Detection of Neisseria meningitidis in a paediatric patient with septic arthritis using multiplexed diagnostic PCR targeting meningitis/encephalitis (ME)

O'Sullivan, Donnchadh; Linnane, Barry; Mostyn, Amanda; Jonathan, Nteimam; Lenihan, Marie; O'Connell, Nuala H.; Dunne, Colum P. (BioMed Central, 2018)

Background: Neisseria meningitidis is associated with meningitis and septicemia. Septic meningococcal arthritis is relatively uncommon and its diagnosis associated with clinical and microbiological challenges. Early ...
Determinants and outcomes of access related blood-stream infections among Irish haemodialysis patients; a cohort study

Mohamed, Husham; Ali, Alaa A.; Browne, Leonard D.; O'Connell, Nuala H.; Casserly, Liam F.; Stack, Austin G.; Hussein, Wael F. (BMC, 2019)

Background: Infections are the second leading cause of death and hospitalisation among haemodialysis (HD) patients. Rates of access-related bloodstream infections (AR-BSI) are influenced by patient characteristics and ...
The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-kB subunits

Mitxitorena, Izaskun; Somma, Domenico; Mitchell, Jennifer P.; Lepistö, Matti; Tyrchan, Christian; Smith, Emma L.; Kiely, Patrick A.; Walden, Helen; Keeshan, Karen; Carmody, Ruaidhrí J. (The American Society for Biochemistry and Molecular Biology, 2020)

The transcription factor NF-kB is a master regulator of the innate immune response and plays a central role in inflammatory diseases by mediating the expression of pro-inflammatory cytokines.Ubiquitination-triggered ...
Developing a guidance resource for managing delirium in patients with Covid-19

Meagher, David; Adamis, Dimitrios; Timmons, Suzanne; O'Regan, Niamh A.; O'Keeffe, Shaun; Kennelly, Sean; Corby, Catherine; Meaney, Anna Maria; Reynolds, Paul; Mohamad, Mas; Glynn, Kevin; O'Sullivan, Roisin (Cambridge University Press, 2020)

As the Covid-19 pandemic escalates worldwide it is apparent that many patients with more severe illness will also experience delirium. These patients pose a particular challenge in the application of optimal care due ...
Developing novel prognostic biomarkers for multivariate fracture risk prediction algorithms

Poku, E.K.; Towler, M.R.; Cummins, Niamh M.; Newman, J.D. (Springer-Verlag, 2012)

Multivariate prediction algorithms such as FRAX® and QFractureScores provide an opportunity for new prognostic biomarkers to be developed and incorporated, potentially leading to better fracture prediction. As more research ...
The development and evaluation of a palliative care admission assessment tool

O'Reilly, Martina (University of Limerick, 2015)

Effective palliative care intervention is contingent upon a comprehensive multidimensional assessment of the patient’s experience of illness. Assessment in palliative care settings must be focused, sensitive, specific and ...
Development and evaluation of an educational intervention in youth mental health for primary care practitioners.

Birrane, John; Swan, Davina; Aherne, Declan; Davis, Rachel; Hannigan, Ailish; McPhillips, David; Meagher, David; O'Regan, Andrew; Ryan, Patrick; Schaffalitzky, Elizabeth; Cullen, Walter (Cambridge University Press, 2015)

Objectives: Irish adolescents have one of the highest rates of suicide and self-harm in the European Union. Although primary care has been identified as an opportune environment in which to detect and treat mental health ...
Development and implementation of a reporting function within electronic medical records

Swan, Davina; Hannigan, Ailish; Higgins, S; McDonnell, Ronan; Meagher, David; Cullen, Walter (2015)

no abstract available

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