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Psychosocial factors are associated with the antibody response to both thymus-dependent and thymus-independent vaccines

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dc.contributor.author Gallagher, Stephen
dc.contributor.author Phillips, Anna C.
dc.contributor.author Ferraro, Alastair J.
dc.contributor.author Drayson, Mark T.
dc.contributor.author Carroll, Douglas
dc.date.accessioned 2013-05-08T09:10:38Z
dc.date.available 2013-05-08T09:10:38Z
dc.date.issued 2008
dc.identifier.uri http://hdl.handle.net/10344/3078
dc.description peer-reviewed en_US
dc.description.abstract The present study examined the association between psychological stress, social support and antibody response to both thymus-dependent and thymus-independent vaccinations. Stressful life events in the previous year and customary social support were measured by standard questionnaires at baseline in 75 (41 females) healthy students. Antibody status was assessed at baseline, 4 and 18 weeks following vaccination with formaldehyde inactivated hepatitis A virus and pneumococcal polysaccharides, which induce thymus-dependent and -independent antibody responses respectively. Controlling for baseline antibody status, life event stress was negatively associated with antibody response to the hepatitis A vaccine at the 18-week follow-up; participants reporting a greater number of stressful life events had a poorer antibody response. There was no relationship between psychological stress and antibody response to pneumococcal vaccination. Social support was not associated with the antibody response to hepatitis A vaccination. However, there was a significant association between support and the antibody response to the thymus-independent pneumococcal vaccine at 4-week followup; participants with larger social networks mounted a better response. These relationships could not be accounted for by age and sex, or by variations in health behaviours. Psychosocial factors would appear to influence the response to both thymusdependent and thymus-independent vaccines, but not in the same manner. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Brain, Behavior and Immunity;22, pp. 456-460
dc.relation.uri http://dx.doi.org/10.1016/j.bbi.2007.10.018
dc.rights This is the author’s version of a work that was accepted for publication in Brain, Behavior and Immunity. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain,Behavior and Immunity vol 22, pp. 456-460 http://dx.doi.org/10.1016/j.bbi.2007.10.018 en_US
dc.subject antibody response en_US
dc.subject hepatitis A vaccination en_US
dc.subject pneumococcal vaccination en_US
dc.subject life events en_US
dc.subject psychological stress en_US
dc.subject social support en_US
dc.title Psychosocial factors are associated with the antibody response to both thymus-dependent and thymus-independent vaccines en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1385205


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