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Social support is positively associated with the immunoglobulin M response to vaccination with pneumococcal polysaccharides

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dc.contributor.author Gallagher, Stephen
dc.contributor.author Phillips, Anna C.
dc.contributor.author Ferraro, Alastair J.
dc.contributor.author Drayson, Mark T.
dc.contributor.author Carroll, Douglas
dc.date.accessioned 2013-05-07T13:52:39Z
dc.date.available 2013-05-07T13:52:39Z
dc.date.issued 2008
dc.identifier.uri http://hdl.handle.net/10344/3075
dc.description peer-reviewed en_US
dc.description.abstract Evidence shows that psychosocial factors are associated with immunoglobulin G response to medical vaccinations. As yet, there are no reports of whether the earlier immunoglobulin M response is similarly susceptible. This study examined the association between psychological stress, social support and the immunoglobulin M response to vaccination with pneumococcal capsular polysaccharides. Stressful life events in the previous year and customary social support were measured by standard questionnaires at baseline in 74 healthy students (41 females). The response to five common pneumococcal serotypes was assessed at baseline and five-days following vaccination. Social support, particularly tangible social support, was positively associated with the antibody response to two of five serotypes, after controlling for baseline titre. These associations survived adjustment for demographics and health behaviours. There was no association between life events stress and immunoglobulin M response. It appears that psychosocial factors affect both the immunoglobulin M and immunoglobulin G responses to vaccination en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Biological Psychology;78, pp. 211-215
dc.relation.uri http://dx.doi.org/10.1016/j.biopsycho.2008.01.001
dc.rights This is the author’s version of a work that was accepted for publication in Biological Psychology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biological Psychology, 2008, 78, pp. 211-215 http://dx.doi.org/10.1016/j.biopsycho.2008.01.001 en_US
dc.subject antibody response en_US
dc.subject immunoglobulin M en_US
dc.subject life events en_US
dc.subject pneumococcal vaccination en_US
dc.subject social support en_US
dc.title Social support is positively associated with the immunoglobulin M response to vaccination with pneumococcal polysaccharides en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1385201


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