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Preliminary evidence that morning vaccination is associated with an enhanced antibody response in men

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dc.contributor.author Phillips, Anna C.
dc.contributor.author Gallagher, Stephen
dc.contributor.author Carroll, Douglas
dc.contributor.author Drayson, Mark T.
dc.date.accessioned 2013-05-07T11:33:14Z
dc.date.available 2013-05-07T11:33:14Z
dc.date.issued 2008
dc.identifier.uri http://hdl.handle.net/10344/3073
dc.description peer-reviewed en_US
dc.description.abstract Variation in response to vaccination, particularly in vulnerable groups, provides a strong rationale for developing vaccine adjuvants. If there were consistent diurnal variation in immune response this could inform a simple intervention for enhancing vaccine efficacy. Data from two studies are presented examining morning versus afternoon vaccine administration; in the first, hepatitis A vaccine was administered to young adults, and in the second, influenza vaccine to older community-based adults. Men, but not women, vaccinated in the morning mounted a better peak antibody response to both hepatitis A and the A/Panama influenza strain. These results indicate that it would be worthwhile testing this effect in a large randomised control trial with vaccination during time periods representing the extremes of hormonal and cytokine diurnal rhythms. en_US
dc.language.iso eng en_US
dc.publisher Wiley-Blackwell en_US
dc.relation.ispartofseries Psychophysiology;45, pp. 663-666
dc.relation.uri http://dx.doi.org/10.1111/j.1469-8986.2008.00662.x
dc.rights This is the author's version of the work that was published in Psychophysiology, 45, pp. 663-666. The definitive version is available at www3.interscience.wiley.com en_US
dc.subject anitbody response en_US
dc.subject diurnal en_US
dc.subject vaccination en_US
dc.title Preliminary evidence that morning vaccination is associated with an enhanced antibody response in men en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1385196


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