University of Limerick Institutional Repository

Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination

DSpace Repository

Show simple item record Gallagher, Stephen Phillips, Anna C. Drayson, Mark T. Carroll, Douglas 2013-05-07T10:41:21Z 2013-05-07T10:41:21Z 2009
dc.description peer-reviewed en_US
dc.description.abstract Objective: Older spousal caregivers of dementia patients have been found to show a relatively poor antibody response to medical vaccination. The present case control study compared the antibody responses to vaccination of younger parental caregivers of children with developmental disabilities and parents of typically developing children. Methods: At baseline assessment, 32 parents of children with developmental disabilities and 29 parents of typically developing children completed standard measures of perceived stress and child problem behaviours. They also provided a blood sample and were then vaccinated with the thymus-dependent trivalent influenza vaccine. Further blood samples were taken at 1- and 6-month follow-ups. Results: Relative to parents of typically developing children (mean titre = 458, SD = 155.7 at 1-month and mean titre = 265, SD = 483.0 at 6-month followup) caregivers (mean titre = 219, SD = 528.4 at 1-month and 86, SD = 55.0 at 6- month) mounted a poorer antibody response than controls to the B/Malaysia strain of the vaccine. It was those caregivers reporting more child problem behaviours that tended to show the weakest antibody response. Conclusion: The negative impact of caregiving on antibody response to vaccination would not appear to be restricted to older spousal caregivers, but is also evident in younger parents caring for children with developmental disabilities. The behavioural characteristics of the care recipients may be a determinant of whether or not antibody response to vaccination is compromised. en_US
dc.language.iso eng en_US
dc.publisher Lippincott, Williams & Wilins en_US
dc.relation.ispartofseries Psychosomatic Medicine;71(33), pp. 341-344
dc.relation.uri 10.1097/PSY.0b013e31819d1910
dc.rights This is the author’s version of a work that was accepted for publication in Psychosomatic Medicine, 71(33), pp. 341.344. The published version of this article is available on line at 10.1097/PSY.0b013e31819d1910. en_US
dc.subject antibody response en_US
dc.subject caregiving en_US
dc.subject children with developmental disabilities en_US
dc.subject child problem behaviours en_US
dc.subject chronic stress en_US
dc.subject influenza vaccination en_US
dc.title Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1385173

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search ULIR


My Account