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A comparative study of the use of powder X-ray diffraction, raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam

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dc.contributor.author Croker, Denise M.
dc.contributor.author Hennigan, Michelle C
dc.contributor.author Maher, Anthony
dc.contributor.author Hu, Yun
dc.contributor.author Ryder, Alan G.
dc.contributor.author Hodnett, Benjamin K.
dc.date.accessioned 2013-04-30T15:55:12Z
dc.date.available 2013-04-30T15:55:12Z
dc.date.issued 2012
dc.identifier.uri http://hdl.handle.net/10344/3066
dc.description peer-reviewed en_US
dc.description.abstract Diffraction and spectroscopic methods were evaluated for quantitative analysis of binary powder mixtures of FII(6.403) and FIII(6.525) Piracetam. The two polymorphs of Piracetam could be distinguished using powder X-ray diffraction (PXRD), Raman and near-infrared (NIR) spectroscopy. The results demonstrated that Raman and NIR spectroscopy are most suitable for quantitative analysis of this polymorphic mixture. When the spectra are treated with the combination of multiplicative scatter correction (MSC) and second derivative data pretreatments, the partial least squared (PLS) regression model gave a root mean square error of calibration (RMSEC) of 0.94 and 0.99 % respectively. FIII(6.525) demonstrated some preferred orientation in PXRD analysis, making PXRD the least preferred method of quantification. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Journal of pharmaceutical and biomedical analysis;63, April 7, pp. 80-86
dc.relation.uri http://dx.doi.org/10.1016/j.jpba.2012.01.013
dc.rights This is the author’s version of a work that was accepted for publication in Journal of Pharmaceutical and Biomedical Analysis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Pharmaceutical and Biomedical Analysis 2012, 63, April 7, pp. 80-86. http://dx.doi.org/10.1016/j.jpba.2012.01.013 en_US
dc.subject piracetam polymorphs en_US
dc.subject quantitative analysi en_US
dc.subject powder X-ray en_US
dc.subject diffraction en_US
dc.subject raman spectroscopy en_US
dc.subject near-infrared spectroscopy en_US
dc.title A comparative study of the use of powder X-ray diffraction, raman and near infrared spectroscopy for quantification of binary polymorphic mixtures of piracetam en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.contributor.sponsor SFI en_US
dc.relation.projectid 07/SRC/B1158 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1387727


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