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The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications

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dc.contributor.author Wren, A.W.
dc.contributor.author Cummins, Niamh M.
dc.contributor.author Laffir, Fathima R.
dc.contributor.author Hudson, Sarah P.
dc.contributor.author Towler, M.R.
dc.date.accessioned 2013-02-26T11:33:04Z
dc.date.available 2013-02-26T11:33:04Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10344/2921
dc.description peer-reviewed en_US
dc.description.abstract The ion release profiles and bioactivity of a series of Ti containing glass polyalkenoate cements (GPCs). Characterization revealed each material to be amorphous with a Tg in the region of 650-660ºC. The network connectivity decreased (1.83-1.35) with the addition of TiO2 which was also evident with analysis by X-ray Photoelectron Spectroscopy (XPS). Ion release from cements were determined using Atomic Absorption Spectroscopy (AAS) for zinc (Zn2+), calcium (Ca2+), strontium (Sr2+), Silica (Si4+) and titanium (Ti4+). Ions such as Zn2+ (0.1-2.0 mg/L), Ca2+ (2.0-8.3 mg/L,) Sr2+ (0.1-3.9 mg/L), and Si4+ (14-90 mg/L) were tested over 1-30 days. No Ti4+ release was detected. Simulated body fluid (SBF) revealed a CaP surface layer on each cement while cell culture testing of cement liquid extracts with TW-Z (5 mol% TiO2) produced the highest cell viability (161%) after 30 days. Direct contact testing of discs resulted in a decrease in cell viability of each cement tested. en_US
dc.language.iso eng en_US
dc.publisher Springer-Verlag en_US
dc.relation.ispartofseries Journal of Materials Science: Materials in Medicine;22(1), pp. 19-28
dc.relation.uri http://dx.doi.org/10.1007/s10856-010-4184-4
dc.rights The original publication is available at www.springerlink.com en_US
dc.subject bioactive glass en_US
dc.subject glass polyalkenoate cement en_US
dc.subject titanium en_US
dc.subject cell culture en_US
dc.title The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1133329


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