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Biological evaluation of nano hydroxyapatite zirconia (HA-ZrO2) composites for load bearing applications.

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dc.contributor.author Brook, Ian
dc.contributor.author Freeman, Christine
dc.contributor.author Grubb, Sarah
dc.contributor.author Cummins, Niamh M.
dc.contributor.author Curran, Declan
dc.contributor.author Reidy, Colin
dc.contributor.author Hampshire, Stuart
dc.contributor.author Towler, M.R.
dc.date.accessioned 2013-02-25T14:27:56Z
dc.date.available 2013-02-25T14:27:56Z
dc.date.issued 2012
dc.identifier.uri http://hdl.handle.net/10344/2913
dc.description peer-reviewed en_US
dc.description.abstract The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatitezirconia (HA-ZrO2) composites produced by employing sol-gel technology, minimal ZrO2 loadings and novel microwave sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favourable response from rat osteosarcoma cells (ROS). In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO2. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be a due to the incorporation of Sr and the formation of a surface apatite layer. en_US
dc.language.iso eng en_US
dc.publisher SAGE Publications en_US
dc.relation.ispartofseries Journal of Biomaterials Applications;27(3), pp. 291-298
dc.relation.uri http://dx.doi.org/10.1177/0885328211403020
dc.subject nano hydroxyapatite en_US
dc.subject DH en_US
dc.subject sol-gel technology en_US
dc.title Biological evaluation of nano hydroxyapatite zirconia (HA-ZrO2) composites for load bearing applications. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.contributor.sponsor EI en_US
dc.relation.projectid TD/2006/328 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1411021


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