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Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a crosssectional, population-based study

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dc.contributor.author Packard, Chris J.
dc.contributor.author Bezlyak, Vladimir
dc.contributor.author McLean, Jennifer S.
dc.contributor.author Batty, David G.
dc.contributor.author Ford, Ian
dc.contributor.author Burns, Harry
dc.contributor.author Cavanagh, Jonathan
dc.contributor.author Deans, Kevin A.
dc.contributor.author Henderson, Marion
dc.contributor.author McGinty, Agnes
dc.contributor.author Millar, Keith
dc.contributor.author Sattar, Naveed
dc.contributor.author Shiels, Paul G.
dc.contributor.author Nathan, Yoga
dc.contributor.author Tannahill, Carol
dc.date.accessioned 2013-02-11T14:34:23Z
dc.date.available 2013-02-11T14:34:23Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10344/2878
dc.description peer-reviewed en_US
dc.description.abstract Background: Socioeconomic gradients in health persist despite public health campaigns and improvements in healthcare. The Psychosocial and Biological Determinants of Ill-health (pSoBid) study was designed to uncover novel biomarkers of chronic disease that may help explain pathways between socioeconomic adversity and poorer physical and mental health. Methods: We examined links between indicators of early life adversity, possible intermediary phenotypes, and markers of ill health in adult subjects (n = 666) recruited from affluent and deprived areas. Classical and novel risk factors for chronic disease (lung function and atherosclerosis) and for cognitive performance were assessed, and associations sought with early life variables including conditions in the parental home, family size and leg length. Results: Associations were observed between father’s occupation, childhood home status (owner-occupier; overcrowding) and biomarkers of chronic inflammation and endothelial activation in adults (C reactive protein, interleukin 6, intercellular adhesion molecule; P < 0.0001) but not number of siblings and leg length. Lung function (forced expiratory volume in 1 second) and cognition (Choice Reaction Time, the Stroop test, Auditory Verbal Learning Test) were likewise related to early life conditions (P < 0.001). In multivariate models inclusion of inflammatory variables reduced the impact and independence of early life conditions on lung function and measures of cognitive ability. Including variables of adult socioeconomic status attenuated the early life associations with disease biomarkers. Conclusions: Adverse levels of biomarkers of ill health in adults appear to be influenced by father’s occupation and childhood home conditions. Chronic inflammation and endothelial activation may in part act as intermediary phenotypes in this complex relationship. Reducing the ‘health divide’ requires that these life course determinants are taken into account. en_US
dc.language.iso eng en_US
dc.publisher BioMed Central Ltd. en_US
dc.relation.ispartofseries BMC Public Health;Jan 17, 11:42
dc.subject socioeconomic adversity en_US
dc.subject chronic disease en_US
dc.subject physical and mental health en_US
dc.title Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a crosssectional, population-based study en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.contributor.sponsor Glasgow Centre for Population Health en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1409378


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