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Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes?

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dc.contributor.author Miller, Ashley M.
dc.contributor.author Purves, David
dc.contributor.author McConnachie, Alex
dc.contributor.author Asquith, Darren L .
dc.contributor.author Batty, David G.
dc.contributor.author Burns, Harry
dc.contributor.author Cavanagh, Jonathan
dc.contributor.author Ford, Ian
dc.contributor.author McLean, Jennifer S.
dc.contributor.author Packard, Chris J.
dc.contributor.author Shiels, Paul G.
dc.contributor.author Turner, Helen
dc.contributor.author Nathan, Yoga
dc.contributor.author Deans, Kevin A.
dc.contributor.author Welsh, Paul
dc.contributor.author McInnes, Iain B.
dc.contributor.author Sattar, Naveed
dc.date.accessioned 2013-02-06T12:19:03Z
dc.date.available 2013-02-06T12:19:03Z
dc.date.issued 2012
dc.identifier.uri http://hdl.handle.net/10344/2868
dc.description peer-reviewed en_US
dc.description.abstract Preliminary data mostly from animal models suggest the sST2/IL-33 pathway may have causal relevance for vascular disease and diabetes and thus point to a potential novel inflammatory link to cardiometabolic disease. However, the characterisation of sST2 levels in terms of metabolic or vascular risk in man is completely lacking. We sought to address this gap via a comprehensive analysis of risk factor and vascular correlates of sST2 in a cross-sectional study (pSoBid). We measured sST2 in plasma in 639 subjects and comprehensively related it to cardiovascular and diabetes risk factors and imaged atherosclerosis measures. Circulating sST2 levels increased with age, were lower in women and in highest earners. After adjusting for age and gender, sST2 levels associated strongly with markers of diabetes, including triglycerides [effect estimate (EE) per 1 standard deviation increase in sST2:1.05 [95%CI 1.01,1.10]), liver function (alanine aminotransaminase [ALT] and c-glutamyl transferase [GGT]: EE 1.05 [1.01,1.09] and 1.13 [1.07,1.19] respectively), glucose (1.02 [1.00,1.03]) and sICAM-1 (1.05 [1.02,1.07]). However, sST2 levels were not related to smoking, cholesterol, blood pressure, or atheroma (carotid intima media thickness, plaque presence). These results suggest that sST2 levels, in individuals largely without vascular disease, are related principally to markers associated with diabetes and ectopic fat and add support for a role of sST2 in diabetes. Further mechanistic studies determining how sST2 is linked to diabetes pathways may offer new insights into the inflammatory paradigm for type 2 diabetes. en_US
dc.language.iso eng en_US
dc.publisher Public Library of Science en_US
dc.relation.ispartofseries PLos One;7(10), e47830
dc.relation.uri http:dx.doi.org/10.1371/journal.pone.0047830
dc.subject diabetes en_US
dc.subject vascular disease en_US
dc.subject cardiovascular en_US
dc.title Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1414594


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