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BIO-SI - Bio-Statistics & Informatics Project

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BIO-SI - Bio-Statistics & Informatics Project

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The Bio-Statistics & Informatics Project is a collaborative SFI research project in Statistical Science between the Centre of Biostatistics, Department of Mathematics & Statistics, University of Limerick, and the Department of Mathematics in NUI Galway.

For more information on the project go to the BIO-SI website.

Recent Submissions

  • MacKenzie, Gilbert; Al-tawarah, Yasin; Blagojevic, Milisa; Burke, Kevin (IWSM, 2018)
    Non-PH parametric survival modelling is developed within the frame- work of the multiple logistic function. The family considered comprises three basic models: (a) a PH model, (b) an accelerated life model and (c) a model ...
  • Peng, Defen; Burke, Kevin; MacKenzie, Gilbert (IWSM, 2018)
    The Weibull multi-parameter regression (MPR) model with frailty is developed for interval censored survival data. The basic MPR model which is wholly parametric with non-proportional hazards was developed by Burke ...
  • Sheikhi, Ali (Univerisyt of Limerick, 2014)
    A single nucleotide polymorphism, or SNP, is a site of the genome where variation occurs within a population. Almost all SNPs have only two alleles (variants). Variations in the DNA sequences of humans can affect how ...
  • MacKenzie, Gilbert; Greig, Mary; Hay, Iris; Pemberton, John (BMJ Publishing Group, 2016)
    Background The 5-year follow-up results for the 1202 middle-aged men prospective study of CHD incidence were published in 1980. This paper extends the follow-up, relating the development of CHD to ten risk factors. Methods The ...
  • MacKenzie, Gilbert; Peng, Defen (2014)
    In the parametric regression models with categorical covariates, it is well known that many key quantities of interest are invariant to the choice of reference subclass. However, surprisingly, not all quantities are ...
  • Sheikhi, Ali; Ramsey, David; MacKenzie, Gilbert (2011)
    A selective sweep occurs when a positive mutation spreads through a population. It causes a reduction in variation among the nucleotides in the neighbourhood of the mutation. Whether or not a selective sweep has occurred can ...
  • MacKenzie, Gilbert; Conde, Susana (IWSM, 2016)
    We develop a Smooth Lasso for sparse, high dimensional, contingency tables and compare its performance with the usual Lasso and with the now classical backwards elimination algorithm. In simulation, the usual Lasso had ...
  • MacKenzie, Gilbert; Do Ha, II (IWSM, 2013)
    The focus is mainly, but, not solely, on longitudinal randomised controlled clinical trials. The paper aims to delineate the role of frailty in the modern analysis of such trials and also in longitudinal survival studies. ...
  • Stembalska, Agnieszka; Leszczynski, Przemyslaw; Gil, Justyna; Ramsey, David; Pitala, Grzegorz; Maciejczyk, Adam; Frączek, Marcin (Wiley, 2014)
    Laryngeal squamous cell carcinoma (LSCC) belongs to the heterogeneous group of head and neck cancers. In the etiology of LSCC, beside important environmental factors, genetic and epigenetic factors play a role in defining ...
  • Ramsey, David (Elsevier, 2012)
    A model of partnership formation based on two traits, called beauty and character, is presented. There are two classes of individual and partners must be of di erent classes. Individuals prefer prospective partners with ...
  • Ramsey, David; Futschik, Andreas (Internaitonal Statistical Institute, 2011)
    An important problem in genetics is detecting single nucleotide polymorphisms (SNPs), sites along the genome at which a population shows variation. The focus is on the detection of rare variants. Pooling individuals ...
  • Alpern, S.; Katrantzi, I.; Ramsey, David (Elsevier, 2013)
    We analyze a model of partnership formation in which players’ preferences are based on the age of a prospective partner. There are two classes of individuals, called for convenience here male and female. Males and females ...
  • Karpinski, Pawel; Myszka, Aleksander; Ramsey, David; Misiak, Blazej; Gil, Justyna; Laczmanska, Izabela; Grzebieniak, Zygmunt; Sebzda, Tadeusz; Smigiel, Robert; Stembalska, Agnieszka; Sasiadek, Maria Malgorzata (Elsevier, 2010)
    The CpG island methylator phenotype (CIMP), together with extensive promoter methylation, is regarded as one of the mechanisms involved in colorectal carcinogenesis (CRC). The mechanisms underlying the presence of CIMP in ...
  • Karpinski, Pawel; Szmida, Elzbieta; Misiak, Blazej; Ramsey, David; Leszczynski, Przemyslaw; Bebenek, Marek; Sedziak, Tomasz; Grzebieniak, Zygmunt; Jonkisz, Anna; Lebioda, Arleta; Sasiadek, Maria Malgorzata (Wiley, 2012)
    Background: Recent investigations have demonstrated the clear heterogeneity of sporadic colorectal cancer (CRC) with regard to CpG island methylation. Two unsupervised cluster analyses revealed that CRCs form three distinct ...
  • Laczmanska, Izabela; Karpinski, Pawel; Bebenek, Marek; Sedziak, Tomasz; Ramsey, David; Szmida, Elżbieta; Sasiadek, Maria Malgorzata (Nature Publishing Group, 2013)
    Introduction: The activity of phosphatases could be influenced by genetic, as well as epigenetic alterations. In our study we have investigated the methylation status of four PTPRs: PTPRM, PTPRT, PTPRR and PTPRZ1, which ...
  • Ramsey, David; Futschik, Andreas (IWSM, 2011)
    We consider the optimal pooling of DNA to detect single nucleotide polymorphisms (SNPs), sites along the genome at which a population shows variation. The focus is on the detection of low frequency variants. Pooling ...
  • Sheikhi, Ali; Ramsey, David (Irish Statistical Association, 2012)
    Genome sequencing includes methods and technologies that are used for determining the order of nucleotides (A, T, C or G) along a DNA sequence. A single nucleotide polymorphism or SNP is a DNA sequence variation occurring ...
  • Sheikhi, Ali; Janghorbani, Mohsen; Soleimani, Bahram (Irish Statistical Association, 2010)
    no abstract available
  • Sheikhi, Ali; Ramsey, David (IWSM, 2012)
    A single nucleotide polymorphism or SNP is a site of the genome where variation occurs within a population. Almost all SNPs have only two alleles (variants). In this work, we consider a statistical method based on a ...
  • Burke, Kevin; MacKenzie, Gilbert (IWSM, 2013)
    The proportional hazards (PH) assumption in survival analysis may not always be appropriate. If data do not obey the assumption then we will reach incorrect conclusions by making it. For example we may find a covariate to ...

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