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ECM-based materials in cardiovascular applications: inherent healing potential and augmentation of native regenerative processes

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Show simple item record Piterina, Anna Valentinova Cloonan, Aidan J. Meaney, Claire L. Davis, Laura M. Callanan, Anthony Walsh, Michael T. McGloughlin, Timothy M. 2012-09-24T14:05:21Z 2012-09-24T14:05:21Z 2009
dc.description peer-reviewed en_US
dc.description.abstract The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced materials composed of decellularised extracellular matrices (ECM) have been shown to promote the healing process via modulation of the host immune response, resistance to bacterial infections, allowing re-innervation and reestablishing homeostasis in the healing region. The physiological balance within the newly developed vascular tissue is maintained via the recreation of correct biorheology and mechanotransduction factors including host immune response, infection control, homing and the attraction of progenitor cells and infiltration by host tissue. Here, we review the progress in this tissue engineering approach, the enhancement potential of ECM materials and future prospects to reach the clinical environment. en_US
dc.language.iso eng en_US
dc.publisher MDPIAG en_US
dc.relation.ispartofseries International Journal of Molecular Sciences;10 (10), pp. 4375-4417
dc.subject vascular grafts en_US
dc.subject ECM en_US
dc.subject healing process en_US
dc.title ECM-based materials in cardiovascular applications: inherent healing potential and augmentation of native regenerative processes en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.contributor.sponsor EI en_US
dc.contributor.sponsor IRCSET en_US
dc.relation.projectid CFTD 2007/131 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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