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Browsing Bernal Institute by Author "Rasmuson, Åke C."

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Browsing Bernal Institute by Author "Rasmuson, Åke C."

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  • Zeglinski, Jacek; Svärd, Michael; Karpinska, Jolanta; Kuhs, Manuel; Rasmuson, Åke C. (Elsevier, 2014)
    In this paper we have explored the relationship between surface structure and crystal growth and morphology of fenoxycarb (FC). Experimental vs. predicted morphologies/face indices of fenoxycarb crystals are presented. ...
  • Zeglinski, Jacek; Kuhs, Manuel; Khamar, Dikshitkumar; Hegarty, Avril C.; Devi, Renuka K.; Rasmuson, Åke C. (Wiley and Sons Ltd, 2018)
    The influence of the solvent in nucleation of tolbutamide, a medium-sized, flexible and polymorphic organic molecule, has been explored by measuring nucleation induction times, estimating solvent-solute interaction ...
  • Lynch, Aisling; Jia, Lijun; Svärd, Michael; Rasmuson, Åke C. (American Chemical Society, 2018)
    Salicylamide was used as a model active pharmaceutical compound to investigate the crystal growth process and its associated kinetics. The impact of organic solvent, supersaturation, and temperature on the crystal growth ...
  • Maher, Anthony (Univeristy of Limerick, 2013)
    The Ph.D project detailed in this thesis investigated the phenomena of crystallisation and polymorphism, focusing on 2-oxo-1-pyrrolidine acetamide (piracetam) as the model compound. The three polymorphs of practical ...
  • Valavi, Masood (University of Limerick, 2017)
    This study investigated two important thermodynamic parameters of crystallisation: the activity coefficient and solubility. The influence of composition and temperature on the activity coefficient was investigated to provide ...
  • Karpinska, Jolanta; Kuhs, Manuel; Rasmuson, Åke C.; Erxleben, Andrea; McArdle, Patrick (International Union of Crystallography, 2012)
    The title compound, C17H19NO4, which is a non-toxic insect growth regulator with the common name fenoxycarb, contains two independent and conformationally different molecules in the asymmetric unit. Although the inter-ring ...
  • O'Mahony, Marcus A; Maher, Anthony; Croker, Denise M.; Rasmuson, Åke C.; Hodnett, Benjamin K. (American Chemical Society, 2012)
    Solution mediated polymorphic transformations (SMPT) of the pharmaceutical compounds carbamazepine and piracetam have been investigated. Seeded transformation experiments were performed, and the solution concentration was ...
  • Heffernan, Claire; Ukrainczyk, Marko; Gamidi, Rama Krishna; Hodnett, Benjamin K.; Rasmuson, Åke C. (American Chemical Society, 2017)
    In this work a method is developed for the extraction and purification of the three curcuminoids; Curcumin (CUR), Demethoxycurcumin (DMC) and Bisdemethoxycurcumin (BDMC) from commercially available crude curcumin. In a ...
  • Svärd, Michael; Rasmuson, Åke C. (American Chemical Society, 2009)
    Molecular simulation is increasingly used by chemical engineers and industrial chemists in process and product development. In particular, the possibility to predict the structure and stability of potential polymorphs of ...
  • Liu, Jin; Svärd, Michael; Rasmuson, Åke C. (American Chemical Society, 2014)
    The influence of agitation and fluid shear on nucleation of m-hydroxybenzoic acid polymorphs from 1-propanol solution has been investigated through 1160 cooling crystallization experiments. The induction time has been ...
  • Liu, Jin; Svärd, Michael; Rasmuson, Åke C. (American Chemical Society, 2015)
    The influence of agitation on nucleation of butyl paraben and m-hydroxybenzoic acid polymorphs has been investigated through 330 cooling crystallization experiments. The induction time has been measured at different ...
  • Kuhs, Manuel; Zeglinski, Jacek; Rasmuson, Åke C. (American Chemical Society, 2014)
    Nearly 1800 induction time experiments have been performed on crystal nucleation of fenoxycarb in isopropanol to investigate the influence of solution pretreatment. For each preheating temperature and preheating time, ...
  • Nordström, Fredrik; Svärd, Michael; Malmberg, Baldur; Rasmuson, Åke C. (American Chemical Society, 2012)
    The influence of solution pretreatment on primary nucleation of m-hydroxybenzoic acid has been investigated through 550 cooling crystallization experiments. The metastable zone width has been determined at constant cooling ...
  • Mealey, Donal; Zeglinski, Jacek; Khamar, Dikshitkumar; Rasmuson, Åke C. (Royal Society of Chemistry, 2015)
    Over 2100 induction time experiments were carried out for the medium-sized, antipsychotic drug molecule, risperidone in seven different organic solvents. To reach the same induction time the required driving force increases ...
  • Heffernan, Claire; Ukrainczyk, Marko; Zeglinski, Jacek; Hodnett, Benjamin K.; Rasmuson, Åke C. (American Chemical Society, 2018)
    In this work, the influence of the structurally related impurities, Demethoxycurcumin (DMC) and Bisdemethoxycurcumin (BDMC) on the primary nucleation of Curcumin (CUR) has been investigated in propan-2-ol. The induction ...
  • Cheuk, Dominic; Svärd, Michael; Seaton, Colin C.; McArdle, Patrick; Rasmuson, Åke C. (Royal Society of Chemistry, 2015)
    Polymorphism, crystal shape and solubility of 1,4-dihydroxyanthraquinone (quinizarin) have been investigated in acetic acid, acetone, acetonitrile, n-butanol and toluene. The solubility of FI and FII from 20 degrees C to ...
  • Tierney, Teresa B.; Guo, Yina; Beloshapkin, Sergey; Rasmuson, Åke C.; Hudson, Sarah P. (American Chemical Society, 2015)
    Submicron to small-micron-sized particles of the hydrophobic drug, fenofibrate, were prepared by controlled crystallization in order to influence its dissolution behavior. An antisolvent precipitation process successfully ...
  • Maher, Anthony; Seaton, Colin C.; Hudson, Sarah P.; Croker, Denise M.; Rasmuson, Åke C.; Hodnett, Benjamin K. (American Chemical Society, 2012)
    The solid-state polymorphic transformations of 2-oxo-1-pyrrolidine acetamide (Piracetam) were investigated using a combination of off-line and on-line techniques; Differential Scanning Calorimetry (DSC), High Temperature ...
  • Svärd, Michael; Rasmuson, Åke C. (American Chemical Society, 2013)
    Nucleation of m-hydroxybenzoic acid crystals in different pure solvents has been investigated, and the thermodynamic interrelationship between two polymorphs was analyzed. The melting properties and specific heat capacities ...
  • O'Mahony, Marcus A; Croker, Denise M.; Rasmuson, Åke C.; Vesler, Stéphane; Hodnett, Benjamin K. (American Chemical Society, 2012)
    The solubility of the stable FIII polymorph of the pharmaceutical compound carbamazepine was measured by determining its solubility gravimetrically in ethanol and methanol. Where the metastable FI polymorph was suspended ...

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