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Browsing Bernal Institute by Author "Keeshan, Karen"

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Browsing Bernal Institute by Author "Keeshan, Karen"

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  • Mitxitorena, Izaskun; Somma, Domenico; Mitchell, Jennifer P.; Lepistö, Matti; Tyrchan, Christian; Smith, Emma L.; Kiely, Patrick A.; Walden, Helen; Keeshan, Karen; Carmody, Ruaidhrí J. (The American Society for Biochemistry and Molecular Biology, 2020)
    The transcription factor NF-kB is a master regulator of the innate immune response and plays a central role in inflammatory diseases by mediating the expression of pro-inflammatory cytokines.Ubiquitination-triggered ...
  • O'Connor, Caitríona; Lohan, Fíona; Campos, Joana; Ohlsson, Ewa; Salomé, Mara; Forde, Ciarán; Artschwager, Raik; Liskamp, Robert M.; Cahill, Mary R.; Kiely, Patrick A.; Porse, Bo; Keeshan, Karen (Springer Nature, 2016)
    C/EBP alpha (p42 and p30 isoforms) is commonly dysregulated in cancer via the action of oncogenes, and specifically in acute myeloid leukaemia (AML) by mutation. Elevated TRIB2 leads to the degradation of C/EBP alpha p42, ...

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