Browsing Bernal Institute by Author "Dalton, Tara"

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Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification

Hayes, Christopher J.; Dowling, Catríona M.; Dwane, Susan; McCumiskey, Mary E.; Tormey, Shona M.; Merrigan, Anne; Coffey, John C.; Kiely, Patrick A.; Dalton, Tara (AIP Publishing, 2016)

In cancer, biomarkers have many potential applications including generation of a differential diagnosis, prediction of response to treatment, and monitoring disease progression. Many molecular biomarkers have been put ...
Microfluidic droplet-based PCR instrumentation for high-throughput gene expression profiling and biomarker discovery

Hayes, Christopher J.; Dalton, Tara (Elsevier, 2015)

PCR is a common and often indispensable technique used in medical and biological research labs for a variety of applications. Real-time quantitative PCR (RT-qPCR) has become a definitive technique for quantitating ...
Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival

Dowling, Catríona M.; Phelan, James L.; Callender, Julia A.; Cathcart, Mary Clare; Mehigan, Brian; McCormick, Paul; Dalton, Tara; Coffey, John C.; Newton, Alexandra C.; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2016)

Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ...

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