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An experimental and numerical comparison of the rupture locations of an abdominal aortic aneurysm

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Show simple item record Doyle, Barry J. Corbett, Timothy J. Callanan, Anthony Walsh, Michael T. Vorp, David A. McGloughlin, Timothy M. 2009-10-13T12:17:46Z 2009-10-13T12:17:46Z 2009
dc.description Peer-reviewed
dc.description.abstract PURPOSE: To identify the rupture locations of idealized physical models of abdominal aortic aneurysm (AAA) using an in-vitro setup and to compare the findings to those predicted numerically. METHODS: Five idealized AAAs were manufactured using Sylgard 184 silicone rubber, which had been mechanically characterized from tensile tests, tear tests, and finite element analysis. The models were then inflated to the point of rupture and recorded using a high-speed camera. Numerical modeling attempted to confirm these rupture locations. Regional variations in wall thickness of the silicone models was also quantified and applied to numerical models. RESULTS: Four of the 5 models tested ruptured at inflection points in the proximal and distal regions of the aneurysm sac and not at regions of maximum diameter. These findings agree with high stress regions computed numerically. Wall stress appears to be independent of wall thickness, with high stress occurring at regions of inflection regardless of wall thickness variations. CONCLUSION: According to these experimental and numerical findings, AAAs experience higher stresses at regions of inflection compared to regions of maximum diameter. Ruptures of the idealized silicone models occurred predominantly at the inflection points, as numerically predicted. Regions of inflection can be easily identified from basic 3-dimensional reconstruction; as ruptures appear to occur at inflection points, these findings may provide a useful insight into the clinical significance of inflection regions. This approach will be applied to patient-specific models in a future study. en
dc.description.sponsorship US National Heart Lung and Blood Institute, USA Grant #R01-HL-060670
dc.description.sponsorship IRCSET (Irish Research Council for Science, Engineering and Technology) Grant RS/2005/340
dc.language.iso eng en
dc.publisher Allen Press en
dc.relation.ispartofseries Journal of Endovascular Therapy;16/3/322-335
dc.subject abdominal aortic aneurysm
dc.title An experimental and numerical comparison of the rupture locations of an abdominal aortic aneurysm en
dc.type Article en
dc.type.supercollection ul_published_reviewed en
dc.type.supercollection all_ul_research
dc.type.restriction none en
dc.contributor.sponsor IRCSET
dc.relation.projectid RS/2005/340 IRCSET
dc.relation.projectid R01-HL-060670 US National Heart Lung and Blood Institute

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