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Browsing Centres Science and Engineering by Author "Duskey, Jason T."

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Browsing Centres Science and Engineering by Author "Duskey, Jason T."

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  • Mulvihill, John J.E.; Cunnane, Eoghan M.; Ross, Aisling M.; Duskey, Jason T.; Tosi, Giovanni; Grabrucker, Andreas M. (Future Medicine, 2020)
    The blood-brain barrier (BBB) has a significant contribution to homeostasis and protection of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the treatment of CNS disorders. To overcome ...
  • Belletti, Daniela; Grabrucker, Andreas M.; Pederzoli, Francesca; Menrath, Isabel; Vandelli, Maria Angela; Tosi, Giovanni; Duskey, Jason T.; Forni, Flavio; Ruozi, Barbara (Elsevier, 2018)
    Restoration of the Chol homeostasis in the Central Nervous System (CNS) could be beneficial for the treatment of Huntington's Disease (HD), a progressive, fatal, adult-onset, neurodegenerative disorder. Unfortunately, Chol ...
  • Pederzoli, Francesca; Ruozi, Barbara; Duskey, Jason T.; Hagmeyer, Simone; Sauer, Ann Katrin; Grabrucker, Stefanie; Coelho, Romina; Oddone, Natalia; Ottonelli, Ilaria; Daini, Eleonora; Zoli, Michele; Vandelli, Maria Angela; Tosi, Giovanni; Grabrucker, Andreas M. (MDPI, 2019)
    The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability ...

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