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Browsing Centres Science and Engineering by Title

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  • Vilkomir, Sergiy A.; Parnas, David Lorge (IEEE Computer Society, 2007)
    This experience and research based paper discusses the reasons that software cannot be trusted and then explains how the use of greatly improved documentation can make software more trustworthy. It shows how tabular ...
  • Sterritt, Ashley; Clarke, Siobhán; Cahill, Vinny (Springer-Verlag, 2010)
    Applying design patterns while developing a software system can improve its non-functional properties, such as extensibility and loose coupling. Precise specification of structure and behaviour communicates the invariants ...
  • Peng, Defen; MacKenzie, Gilbert (IWSM, 2011)
    Recently, several advances have been made in the analysis of interval censored (IC) data mainly in relation to semi-parametric proportional hazard (PH) models (Gómez et al., 2009, Lesaffre et al., 2005). It is arguable, ...
  • Gamidi, Rama Krishna; Ukrainczyk, Marko; Zeglinski, Jacek; Rasmuson, Åke C. (American Chemical Society, 2018)
    Using Artificial Neural Networks (ANNs), four distinct models have been developed for the prediction of solid-state properties of cocrystals: melting point, lattice energy, and crystal density. The models use three input ...
  • Houston, Aileen; Williams, John M; Rovis, Tihana Lenac; Shanley, Daniel K.; O'Riordan, Ronan T.; Kiely, Patrick A.; Ball, Melanie; Barry, Orla P; Kelly, Jacquie; Fanning, Aine; MacSharry, John; Mandelboim, Ofer; Singer, Bernhard B; Jonjic, Stipan; Moore, Tom (Taylor and Francis, 2016)
    Pregnancy-specific glycoproteins (PSGs) are immunoglobulin superfamily members related to the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family and are encoded by 10 genes in the human. They are ...
  • Shanley, Daniel K.; Kiely, Patrick A.; Golla, Kalyan; Allen, Seamus; Martin, Kenneth; O'Riordan, Ronan T.; Ball, Melanie; Aplin, John D.; Singer, Bernard B; Caplice, Noel; Moran, Niamh; Moore, Tom (Public Library of Science, 2013)
    Pregnancy-specific glycoproteins (PSGs) are immunoglobulin superfamily members encoded by multigene families in rodents and primates. In human pregnancy, PSGs are secreted by the syncytiotrophoblast, a fetal tissue, and ...
  • Hayes, John A; Eccles, Kevin S; Lawrence, Simon E; Moynihan, Humphrey A (Elsevier, 2012)
    The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In ...
  • Mesallati, Hanah; Conroy, Daryl; Hudson, Sarah P.; Tajber, Lidia (Elsevier, 2017)
    The amorphization of the poorly soluble drug ciprofloxacin (CIP) may be facilitated by the use of a suitable stabilizer. In this study seven amino acids, with various side chain properties, were evaluated in this ...
  • Nordström, Fredrik; Svärd, Michael; Rasmuson, Åke C. (2013)
    The onset of nucleation of salicylamide in organic solvents has been measured for a total of 2911 nucleation experiments at a constant cooling rate. The experiments are divided into series of different experimental conditions ...
  • Gancarski, Pawel; Butterfield, Andrew (Springer-Verlag, 2010)
    This paper describes an extension adding priority to slotted-Circus, a generic framework for reasoning about discretely timed and/or synchronously clocked systems. The semantics of prioritised external choice is given using ...
  • Parnas, David Lorge (2003)
    Improperly designed interfaces can make modular programs almost indistinguishable from monoliths. An interface encapsulates design decisions only if it need not be changed when those design decisions are changed. This talk ...
  • Kiri, Victor A (Maney Publishing, 2012)
    Pharmacoepidemiological studies based on the cohort design are simpler to analyse and their results easier to interpret. However, these may not reflect real-life drug use which is a major strength of such studies. The ...
  • Bezuidenhout, Michael; Liu, Pai; Singh, Shalini; Kiely, Maeve; Ryan, Kevin M.; Kiely, Patrick A. (Public Library of Science, 2014)
    Group IV Nanowires have strong potential for several biomedical applications. However, to date their use remains limited because many are synthesised using heavy metal seeds and functionalised using organic ligands to make ...
  • O'Sullivan, Catriona; Crilly, Suzanne; Laffir, Fathima R.; Singh, Ajay; Magner, Edmond; Ryan, Kevin M. (Royal Society of Chemistry, 2011)
    A multi component assembly consisting of the redox protein cytochrome c (cyt c) immobilised onto vertically aligned gold tipped semiconductor nanorods is described. Cyt c was 10 successfully immobilised using a thiol linker. ...
  • Dowling, Catríona M; Phelan, James L.; Callender, Julia A; Cathcart, Mary Clare; Mehigan, Brian; McCormick, Paul; Dalton, Tara; Coffey, John C; Newton, Alexandra C; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2016)
    Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ...
  • Laczmanska, Izabela; Karpinski, Pawel; Bebenek, Marek; Sedziak, Tomasz; Ramsey, David; Szmida, Elżbieta; Sasiadek, Maria Malgorzata (Nature Publishing Group, 2013)
    Introduction: The activity of phosphatases could be influenced by genetic, as well as epigenetic alterations. In our study we have investigated the methylation status of four PTPRs: PTPRM, PTPRT, PTPRR and PTPRZ1, which ...
  • Ciolino, Joseph B; Hudson, Sarah P.; Mobbs, Ashley N; Hoare, Todd R; Iwata, Naomi G; Fink, Gerald R; Kohane, Daniel S (Association for Research in Vision and Ophthalmology (ARVO), 2011)
    PURPOSE. To design a contact lens to treat and prevent fungal ocular infections.METHODS. Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl ...
  • Hudson, Sarah P.; Tanner, David A; Redington, W; Magner, Edmond; Hodnett, Benjamin K; Nakahara, S (Royal Society of Chemistry, 2006)
    TEM analysis of mesoporous materials is generally undertaken to give qualitative results. Accurate quantitative analysis is demonstrated in this study. A systematic image analysis of a powder form of a hexagonal mesoporous ...
  • Dolan, G.P; Flynn, Robert, Joseph; Tanner, David A; Robinson, J.S (Maney Publishing, 2005)
    Determination of the time-temperature property C curve for aluminium alloys usually involves a large number of quenches and isothermal holds to calibrate a set of constants that describes the shape of the C curve for a ...
  • Robinson, J.S; Cudd, Richard L; Tanner, David A; Dolan, G.P (Elsevier, 2001)
    7xxx (Al-Zn-Mg-Cu) alloys develop their strength, through the controlled decomposition (ageing) of a supersaturated solid solution to produce a precipitation hardened microstructure. The supersaturated solid solution is ...

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