• Asymptotic analysis of the dominant mechanisms in the coffee extraction process 

  Moroney, Kevin M.; Lee, William T.; O'Brien, Stephen B.G.; Suijver, F.; Marra, Johan (Society for Industrial and Applied Mathematics, 2016)

  Extraction of coffee solubles from roast and ground coffee is a highly complex process, depending on a large number of brewing parameters. We consider a recent, experimentally validated, model of coffee extraction, describing ...
• The presence of C/EBP alpha and its degradation are both required for TRIB2-mediated leukaemia 

  O'Connor, Caitríona; Lohan, Fíona; Campos, Joana; Ohlsson, Ewa; Salomé, Mara; Forde, Ciarán; Artschwager, Raik; Liskamp, Robert M.; Cahill, Mary R.; Kiely, Patrick A.; Porse, Bo; Keeshan, Karen (Springer Nature, 2016)

  C/EBP alpha (p42 and p30 isoforms) is commonly dysregulated in cancer via the action of oncogenes, and specifically in acute myeloid leukaemia (AML) by mutation. Elevated TRIB2 leads to the degradation of C/EBP alpha p42, ...
• Analytic loss minimization: a proof 

  Cuffe, Paul; Dassios, Ioannis K.; Keane, Andrew (IEEE Computer Society, 2016)

  Abstract—Loss minimizing generator dispatch profiles for power systems are usually derived using optimization techniques. However, some authors have noted that a system’s KGL matrix can be used to analytically determine ...
• Prediction of the solubility of medium-sized pharmaceutical compounds using a temperature-dependent NRTL-SAC model 

  Valavi, Masood; Svärd, Michael; Rasmuson, Åke C. (American Chemical Society, 2016)

  In this work, the NRTL-SAC and the Pharma UNIFAC models are evaluated with respect to the capability of prediction of solid liquid equilibria of pharmaceutical compounds in organic solvents. The original NRTL-SAC model is ...
• Improving estimates of the crystallization driving force: investigation into the dependence on temperature and composition of activity coefficients in solution 

  Svärd, Michael; Valavi, Masood; Rasmuson, Åke C. (American Chemical Society, 2016)

  In this work the influence of temperature and composition on the activity coefficient in solution has been investigated, based on isothermal and isobaric vapor-liquid equilibrium data for 30 binary systems classified into ...
• Calorimetric properties and solubility in five pure organic solvents of N-Methyl-D-Glucamine (Meglumine) 

  Svärd, Michael; Hjorth, Timothy; Bohlin, Martin; Rasmuson, Åke C. (American Chemical Society, 2016)

  The solid liquid solubility of the title compound has been measured by a gravimetric method in five pure organic solvents over the temperature range (283 to 323) K. The melting temperature and associated enthalpy of fusion ...
• Thermodynamic stability analysis of tolbutamide polymorphs and solubility in organic solvents 

  Svärd, Michael; Valavi, Masood; Khamar, Dikshitkumar; Kuhs, Manuel; Rasmuson, Åke C. (Elsevier, 2016)

  Melting temperatures and enthalpies of fusion have been determined by differential scanning calorimetry (DSC) for 2 polymorphs of the drug tolbutamide: FIH and FV. Heat capacities have been determined by temperature-modulated ...
• Nilvadipine in mild to moderate alzheimer disease: a randomised controlled trial 

  Lawlor, Brian; Segurado, Ricardo; Kennelly, Sean; Olde Rikkert, Marcel G. M.; Howard, Robert; Pasquier, Florence; Borjesson-Hanson, Anne; Tsolaki, Magda; Lucca, Ugo; William Molloy, D; Coen, Robert; Riepe, Matthias W.; Kálmán, János; Kenny, Rose Anne; Cregg, Fiona; O'Dwyer, Sarah; Walsh, Cathal; Adams, Jessica; Banzi, Rita; Breuilh, Laetitia; Daly, Leslie; Hendrix, Suzanne; Aisen, Paul; Gaynor, Siobhan; Sheikhi, Ali; Taekema, Diana G.; Verhey, Frans R.; Nemni, Raffaello; Nobili, Flavio; Franceschi, Massimo; Frisoni, Giovanni; Zanetti, Orazio; Konsta, Anastasia; Anastasios, Orologas; Nenopoulou, Styliani; Tsolaki-Tagaraki, Fani; Pakaski, Magdolna; Dereeper, Olivier; de la Sayette, Vincent; Sénéchal, Olivier; Lavenu, Isabelle; Devendeville, Agnés; Calais, Gauthier; Crawford, Fiona; Mullan, Michael (Public Library of Science, 2018)

  Background This study reports the findings of the first large-scale Phase III investigator-driven clinical trial to slow the rate of cognitive decline in Alzheimer disease with a dihydropyridine (DHP) calcium channel ...
• Aligned copper zinc tin sulfide nanorods as lithium-ion battery anodes with high specific capacities 

  Bree, Gerard; Geaney, Hugh; Stokes, Killian; Ryan, Kevin M. (American Chemical Society, 2018)

  Highly aligned copper zinc tin sulfide nanorods electrophoretically deposited directly on the current collector are tested for suitability as Li-ion battery anodes in both half-cell (HC) and full-cell (FC) configurations. ...
• Effects of scale-up on the mechanism and kinetics of crystal nucleation 

  Steendam, René R.E.; Keshavarz, Leila; Blijlevens, Melian A.R.; de Souza, Brian P.; Croker, Denise M.; Frawley, Patrick J. (American Chemical Society, 2018)

  Insight into nucleation kinetics and other nucleation parameters can be obtained from probability distributions of induction time measurements in combination with the classical nucleation theory. In this work, induction ...
• Annealing environment effects on the electrochemical behavior of supercapacitors using Ni foam current collectors 

  Jadhav, Vijaykumar V.; Kore, Ronan M.; Thorat, Nanasaheb D.; Yun, Je Moon; Ho Kim, Kwang; Mane, Rajaram S.; O'Dwyer, Colm (IOP Publishing, 2018)

  Nickel (Ni) foam-based symmetric/asymmetric electrochemical supercapacitors benefit from a randomly 3D structured porous geometry that functions as an active material support and as a current collector. The surface composition ...
• The impact of individual patient data in a network meta-analysis: an investigation into parameter estimation and model selection 

  Leahy, Joe; O'Leary, Aisling; Afdhal, Nezam; Gray, Emma; Milligan, Scott; Wehmeyer, Malte H.; Walsh, Cathal (Wiley and Sons Ltd, 2018)

  The use of individual patient data (IPD) in network meta-analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, most NMAs are performed using aggregate data for at least some, if not ...
• MRCZ – A file format for cryo-TEM data with fast compression 

  McLeod, Robert A.; Righetto, Ricardo Diogo; Stewart, Andy; Stahlberg, Henning (Elsevier, 2018)

  The introduction of fast CMOS detectors is moving the field of transmission electron microscopy into the computer science field of big data. Automated data pipelines control the instrument and initial processing steps which ...
• Additive manufacturing: scientific and technological challenges, market uptake and opportunities 

  Tofail, Syed A.M.; Koumoulos, Elias P.; Bandyopadhyay, Amit; Bose, Susmita; O'Donoghue, Lisa; Charitidis, Costas A. (Elsevier, 2018)

  Additive manufacturing (AM) is fundamentally different from traditional formative or subtractive manufacturing in that it is the closest to the ‘bottom up’ manufacturing where a structure can be built into its designed ...
• Microfluidic chambers using fluid walls for cell biology 

  Soitu, Cristian; Feuerborn, Alexander; Tan, Ann Na; Walker, Henry; Walsh, Pat A.; Castrejón-Pita, Alfonso A.; Cook, Peter R.; Walsh, Edmond J. (PNAS:, 2018)

  Many proofs of concept have demonstrated the potential of microfluidics in cell biology. However, the technology remains inaccessible to many biologists, as it often requires complex manufacturing facilities (such as ...
• Sinking bubbles in stout beers 

  Lee, William T.; Kaar, S.; O'Brien, Stephen B.G. (American Assocation of Physics Teachers, 2018)

  A surprising phenomenon witnessed by many is the sinking bubbles seen in a settling pint of stout beer. Bubbles are less dense than the surrounding fluid so how does this happen? Previous work has shown that the explanation ...
• Cell deformation in response to long term hyperosmotic loading 

  van Donkelaar, C.C.; Daniëls, M.A.; Huyghe, Jacques M. (Wroclaw University of Science and Technology, 2018)
• Characterizing the analogy between hyperbolic embedding and community structure of complex networks 

  Faqeeh, Ali; Osat, Saeed; Radicchi, Filippo (American Physical Society, 2018)

  We show that the community structure of a network can be used as a coarse version of its embedding in a hidden space with hyperbolic geometry. The finding emerges from a systematic analysis of several real-world and ...
• Creating cocrystals: a review of pharmaceutical cocrystal preparation routes and applications 

  Karimi-Jafari, Maryam; Padrela, Luis; Walker, Gavin M.; Croker, Denise M. (American Chemical Society, 2018)

  Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals. Intensification ...
• Intra-extrafibrillar mixture formulation of soft charged tissues 

  Huyghe, Jacques M. (Polish Society of Theoretical and Applied Mechanics, 1999)

  The volume of the intrafibrillar water space - i.e. the water contained inside the collagen fibers - is a key parameter that is relevant to concepts of connective tissue structure and function. Because existing theories of ...

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