Browsing Mathematics & Statistics by Subject "genome sequencing"

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A likelihood ratio test for detection of single nucleotide polymorphisms (SNPs)

Sheikhi, Ali; Ramsey, David (IWSM, 2012)

A single nucleotide polymorphism or SNP is a site of the genome where variation occurs within a population. Almost all SNPs have only two alleles (variants). In this work, we consider a statistical method based on a ...
Optimal DNA pooling for the detection of single nucleotide polymorphisms

Ramsey, David; Futschik, Andreas (IWSM, 2011)

We consider the optimal pooling of DNA to detect single nucleotide polymorphisms (SNPs), sites along the genome at which a population shows variation. The focus is on the detection of low frequency variants. Pooling ...
Statistical methods for the detection of single nucleotide polymorphisms (SNPs) using new generation genome sequencers

Sheikhi, Ali; Ramsey, David (Irish Statistical Association, 2012)

Genome sequencing includes methods and technologies that are used for determining the order of nucleotides (A, T, C or G) along a DNA sequence. A single nucleotide polymorphism or SNP is a DNA sequence variation occurring ...

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