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  • Lawlor, Brian; Kennelly, Sean; O'Dwyer, Sarah; Cregg, Fiona; Walsh, Cathal Dominic; Cohen, Robert; Kenny, Rose Anne; Howard, Robert; Murphy, Caroline; Adams, Jessica; Daly, Leslie; Segurado, Ricardo; Gaynor, Siobhan; Crawford, Fiiona; Mullan, Michael; Lucca, Ugo; Banzi, Rita; Pasquier, Florence; Breuilh, Laetitia; Riepe, Matthias; Kalman, Janos; Wallin, Anders; Borjesson, Anne; Molloy, William; Tsolaki, Magda; Rikkert, Marcel Olde (BMJ Publshing Group, 2014)
    This study is a European multicentre, randomised, double-blind, placebo-controlled trial investigating the efficacy and safety of nilvadipine as a disease course modifying treatment for mild-tomoderate Alzheimer’s ...
  • Lawlor, Brian; Segurado, Ricardo; Kennelly, Sean; Olde Rikkert, Marcel G. M.; Howard, Robert; Pasquier, Florence; Borjesson-Hanson, Anne; Tsolaki, Magda; Lucca, Ugo; William Molloy, D; Coen, Robert; Riepe, Matthias W.; Kálmán, János; Kenny, Rose Anne; Cregg, Fiona; O'Dwyer, Sarah; Walsh, Cathal Dominic; Adams, Jessica; Banzi, Rita; Breuilh, Laetitia; Daly, Leslie; Hendrix, Suzanne; Aisen, Paul; Gaynor, Siobhan; Sheikhi, Ali; Taekema, Diana G.; Verhey, Frans R.; Nemni, Raffaello; Nobili, Flavio; Franceschi, Massimo; Frisoni, Giovanni; Zanetti, Orazio; Konsta, Anastasia; Anastasios, Orologas; Nenopoulou, Styliani; Tsolaki-Tagaraki, Fani; Pakaski, Magdolna; Dereeper, Olivier; de la Sayette, Vincent; Sénéchal, Olivier; Lavenu, Isabelle; Devendeville, Agnés; Calais, Gauthier; Crawford, Fiona; Mullan, Michael (Public Library of Science, 2018)
    Background This study reports the findings of the first large-scale Phase III investigator-driven clinical trial to slow the rate of cognitive decline in Alzheimer disease with a dihydropyridine (DHP) calcium channel ...
  • Al-tawarah, Yasin; MacKenzie, Gilbert (IWSM, 2003)
    In longitudinal studies with a set of continuous or ordinal repeated response variables it may be convenient to summarize the outcome as a threshold event. Then, the time to this event becomes of interest. In this paper ...
  • MacKenzie, Gilbert; Do Ha, II; Lee, Youngjo (IWSM, 2003)
    Correlated survival times may be modelled by introducing a random effect, or frailty, component into the hazard function. For multivariate survival data we extend a non-PH model, the generalized time-dependent logistic (GTDL) ...
  • MacKenzie, Gilbert; Al-tawarah, Yasin; Blagojevic, Milisa; Burke, Kevin (IWSM, 2018)
    Non-PH parametric survival modelling is developed within the frame- work of the multiple logistic function. The family considered comprises three basic models: (a) a PH model, (b) an accelerated life model and (c) a model ...
  • Al-tawarah, Yasin; MacKenzie, Gilbert (IWSM, 2005)
    In this paper we investigate the use of accelerated Weibull hazard model. We compare it with Logistic Accelerated Hazard model. The models are used to analyze survival data from the Northern Ireland lung cancer study ...
  • Donovan, J; Murphy, Eamonn (Irish Statistical Association, 2007)
    Commercial irradiation typically involves applying electron beam or gamma radiation to a product with a view to sterilizing the product and killing any bacteria present. This is extremely important in the medical ...
  • Timoney, Catherine M. (University of Limerick, 2017)
    This work is concerned with finding accurate numerical approximations to nonlinear reaction-diffusion problems that exhibit layer phenomena. It considers three variations of problems of this type. These are; a ...
  • Moyles, Iain R.; Wetton, Brian (Elsevier, 2015)
    We present a numerical framework for solving localized pattern structures of reaction-diffusion type far from the Turing regime. We exploit asymptotic structure in a set of well established pattern formation problems to ...
  • Fannon, James S.; Fowler, Andrew C.; Moyles, Iain R. (The Royal Society Publishing, 2017)
    We summarize the present form of the instability theory for drumlin formation, which describes the coupled subglacial flow of ice, water and sediment. This model has evolved over the last 20 years, and is now at the point ...
  • Khaleque, Tania S; Fowler, Andrew C.; Howell, P D; Vynnycky, Michael (American Institute of Physics, 2015)
    Motivated by convection of planetary mantles, we consider a mathematical model for Rayleigh-Benard convection in a basally heated layer of a fluid whose viscosity depends strongly on temperature and pressure, defined in ...
  • Lynch, Joseph; MacKenzie, Gilbert (IWSM, 2011)
    We compare and contrast the properties of the bivariate Weibull and GTDL regression survival models. An analytic expression for the correlation between times is derived for the Weibull model and a modified Kullback-Lei ...
  • Benilov, Eugene (European Geosciences Union (EGU) International, 1999)
    The evolution of tracer "injected" into an equivalent barotropic eddy on the beta-plane is examined numerically. The eddy is governed by the standard quasigeostrophic equation, and the concentration of tracer is governed ...
  • Peng, Defen; MacKenzie, Gilbert (IWSM, 2007)
    We develop an analysis of the reliability of reliability data following a negative exponential distribution and subject to type I censoring. Our main focus is to determine the role of the particular analytical approach ...
  • Vynnycky, Michael; Saleem, S.; Devine, K .M.; Florio, B. J.; Mitchell, Sarah L.; O'Brien, Stephen B.G. (The Royal Society, 2017)
    Asymptotic methods are employed to revisit an earlier model for oscillation-mark formation in the continuous casting of steel. A systematic non-dimensionalization of the governing equations, which was not carried out ...
  • Louzada-Neto, Francisco; MacKenzie, Gilbert; Cremasco, Caroline Pires; Ferreira-Silva, Paulo Henrique (UNESP, 2011)
    In order to accommodating crossing hazard curves, which are non- proportional hazards, we consider in this paper a generalized time-dependent logistic hazard survival model, which has a time-dependent term. The model is ...
  • Dassios, Ioannis K.; Cuffe, Paul; Keane, Andrew (2015)
    Electrical power system calculations rely heavily on the Y_{bus} matrix, which is the Laplacian matrix of the network under study, weighted by the complex-valued admittance of each branch. It is often useful to partition ...
  • Berkery, Elaine C.; Morley, Michael; Tiernan, Siobhán; Purtill, Helen; Parry, Emma (John Wiley and Sons Ltd., 2017)
    The aim of this study was to identify bundles of flexible working arrangements (FWAs) from data provided by 1,064 organizations in seven EU countries, and to relate bundle membership to demographic variables and human ...
  • Villiers, Rory (University of Limerick, 2011)
    The most common method of pricing a cashflow collateralized debt obligation (cashflow CDO) is to use Monte Carlo integration. However, Monte Carlo integration is computationally intensive and often faster methods of ...
  • Ramsey, David; Futschik, Andreas (IWSM, 2011)
    We consider the optimal pooling of DNA to detect single nucleotide polymorphisms (SNPs), sites along the genome at which a population shows variation. The focus is on the detection of low frequency variants. Pooling ...

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