Background: Epidemiological data show that colorectal cancer (CRC) is the second most frequent malignancy worldwide. The involvement of “minor impact genes” such as XME and DNA-repair genes in the etiology of sporadic ...

The network topologies on which many natural and synthetic systems are built provide ideal settings for the emergence of complex phenomena. One well-studied manifestation of this, called a cascade or avalanche, is observed ...

We present an analytical approach to determining the expected cascade size in a broad range of dynamical models on the class of highly clustered random graphs introduced by Gleeson [J. P. Gleeson, Phys. Rev. E 80, 036107 ...

Background Pain is common in older adults, and associated with increased morbidity and reduced quality of life. Recent research has highlighted different classes of older adults with pain, each with differing impacts ...

In the parametric regression models with categorical covariates, it is well known that many key quantities of interest are invariant to the choice of reference subclass. However, surprisingly, not all quantities are ...

Background: One-size-fits-all interventions reduce chronic low back pain (CLBP) a small amount. An individualised intervention called cognitive functional therapy (CFT) was superior for CLBP compared with manual therapy ...

Nonspecific chronic spinal pain (NSCSP) is highly disabling. Current conservative rehabilitation commonly includes physical and behavioral interventions, or a combination of these approaches. Physical interventions aim to ...

One hundred and thirty seven previously untreated outpatients with first and second degree haemorrhoids were allocated at random to treatment by infrared coagulation (n=66) or rubber band ligation (n= 71). Complete ...

Background The 5-year follow-up results for the 1202 middle-aged men prospective study of CHD incidence were published in 1980. This paper extends the follow-up, relating the development of CHD to ten risk factors. Methods The ...

Heavy-tailed distributions of meme popularity occur naturally in a model of meme diffusion on social networks. Competition between multiple memes for the limited resource of user attention is identified as the mechanism ...