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Single point and imaging measurements of the optical clearing process

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dc.contributor.author Enfield, Joey
dc.contributor.author O'Doherty, Jim
dc.contributor.author Leahy, Martin J.
dc.date.accessioned 2009-03-10T09:23:37Z
dc.date.available 2009-03-10T09:23:37Z
dc.date.issued 2007
dc.identifier.citation Enfield, J., O'Doherty, J. and Leahy, M.J. (2007) 'Single point and iimaging measurements of the optical clearing process' SPIE-OSA, 6631, 66311E-1 en
dc.identifier.uri http://hdl.handle.net/10344/128
dc.description non-peer-reviewed
dc.description.abstract Biomedical optics and photomedicine applications are challenged by the turbid nature of most biological tissue systems. This nature limits the penetration depth of light into the tissue. Optical clearing improves the penetration depth of light by the application of optical clearing agents which produce an equalization of refractive indices between tissue components and causes a decrease in tissue scattering, and thus increase in optical transmittance. In this paper we examine the effects of optical clearing agents on ex vivo porcine skin using the immersion method. We develop a simple model that can be used to compare different aspects of optical clearing agents such as the rate at which the clearing agents enters the tissue and also the reduction in scattering achieved. We examine the change in the reflected light spectrum over time as the clearing agent enters the skin. This is examined via point probe measurements and also a wide field imaging technique with a consumer-end digital camera. The consumer-end digital camera offers a cheap and simple method for analyzing optical clearing agents over a wider field,. overcoming the limitations of single point measurements. en
dc.language.iso eng en
dc.publisher SPIE - Society of Photo‑Optical Instrumentation Engineers en
dc.relation.ispartofseries Novel Optical Instrumentation for Biomedical Applications III;6631/ 66311E
dc.relation.uri http://dx.doi.org/10.1117/12.728490
dc.rights Copyright 2007 Society of Photo‑Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. en
dc.subject infrared reflectance spectroscopy en
dc.subject coherence tomography en
dc.subject tissues en
dc.subject agents en
dc.subject skin en
dc.title Single point and imaging measurements of the optical clearing process en
dc.type Conference item en
dc.type.supercollection all_ul_research en
dc.type.restriction none en
dc.contributor.sponsor IRCSET


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