Browsing Life Sciences by Title

Now showing items 110-129 of 165

Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2

Sarowar, Tasnuva; Grabucker, Stefanie; Boeckers, Tobias M; Grabucker, Andreas M (Frontiers Medai, 2017)

RICH2 knockout (RICH2 KO) mice exhibit neophobia in the novel object test. To gain further insight into their anxiety-related phenotype, we subjected these mice to additional behavioral tests to elucidate whether the ...
An objective measure of noseband tightness and Its measurement using a novel digital tightness gauge

Doherty, Orla M; Conway, Thomas; Conway, Richard; Murray, Gerard; Casey, Vincent (Public Library of Science, 2017)

Noseband tightness is difficult to assess in horses participating in equestrian sports such as dressage, show jumping and three-day-eventing. There is growing concern that nosebands are commonly tightened to such an extent ...
An open source tool for automated input data in simulation

Barlas, Panagiotis; Heavey, Cathal; Dagkakis, Georgios (D A A A M International Vienna, 2015)

Discrete Event Simulation (DES) is one of the most effective tools for planning, designing and improving material flows in production. One of the main weaknesses of operating DES is the exertion needed and costs spent on ...
Opioid peptides encrypted in intact milk protein sequences

Meisel, Hans; Fitzgerald, Richard J. (Cambridge University Press, 2000)

Opioid agonistic and antagonistic peptides which are inactive within the sequence of the precursor milk proteins can be released and thus activated by enzymatic proteolysis, for example during gastrointestinal digestion ...
Optimising parameters for the differentiation of SH-SY5Y cells to study cell adhesion and cell migration

Dwane, Susan; Durack, Edel; Kiely, Patrick A (BioMed Central, 2013)

Background: Cell migration is a fundamental biological process and has an important role in the developing brain by regulating a highly specific pattern of connections between nerve cells. Cell migration is required for ...
Ovine and caprine lipids promoting cardiovascular health in milk and its derivatives

Lordan, Ronan; Zabetakis, Ioannis (OMICS International, 2017)

The purpose of this commentary is to highlight the anti-inflammatory properties of polar lipids present in ovine and caprine milk and its derivatives (i.e. dairy products such as yogurt and cheese). These lipids inhibit ...
Oxalate secretion by ectomycorrhizal Paxillus involutus is mineral-specific and controls calcium weathering from minerals

Schmalenberger, Achim; Duran, A.L; Bray, A.W; Bridge, J; Bonneville, S; Benning, L.G; Romero-Gonzalez, M.E; Leake, J.R; Banwart, S.A (Nature Publishing Group, 2015)

Trees and their associated rhizosphere organisms play a major role in mineral weathering drivingcalcium fluxes from the continents to the oceans that ultimately control long-term atmosphericCO2 and climate through the ...
Partitioning of soil respiration in a beech forest using a trenching experiment.

Brosnan, Stephanie (University of Limerick, 2011)

Total soil respiration (RTOT) has two components; heterotrophic (RH) and autotrophic (RA) respiration. We aim to partition the components of RTOT in a beech (Fagus sylvatica L.) forest using a trenching experiment. The ...
Performance and progression of Irish point-to-point horses

Quish, Carol (University of Limerick, 2011)

Point-to-point races are steeplechase races for novice horses, some of which may subsequently graduate to professional National Hunt (NH) races on the racecourse. There have been significant changes in the Irish racing ...
Physicochemical and sensory characteristics of whey protein hydrolysates generated at different total solids levels

Spellman, David; O'Cuinn, Gerard; Fitzgerald, Richard J. (Cambridge University Press, 2005)

Whey protein hydrolysates were generated at different total solids (TS) levels (50–300 g/l) using the commercially available proteolytic preparation DebitraseTM HYW20, while enzyme to substrate ratio, pH and temperature ...
Predator versus prey: locust looming-detector neuron and behavioural responses to stimuli representing attacking bird predators

Santer, Roger D; Rind, Claire F; Simmons, Peter J (Public Library of Science, 2012)

Many arthropods possess escape-triggering neural mechanisms that help them evade predators. These mechanisms are important neuroethological models, but they are rarely investigated using predator-like stimuli because there ...
Pregnancy-specific glycoproteins bind integrin alpha IIb beta 3 and inhibit the platelet-fibrinogen interaction

Shanley, Daniel K; Kiely, Patrick A; Golla, Kalyan; Allen, Seamus; Martin, Kenneth; O'Riordan, Ronan T; Ball, Melanie; Aplin, John D; Singer, Bernard B; Caplice, Noel; Moran, Niamh; Moore, Tom (Public Library of Science, 2013)

Pregnancy-specific glycoproteins (PSGs) are immunoglobulin superfamily members encoded by multigene families in rodents and primates. In human pregnancy, PSGs are secreted by the syncytiotrophoblast, a fetal tissue, and ...
Profiling of the molecular weight and structural isomer abundance of macroalgae-derived phlorotannins

Heffernan, Natalie; Brunton, Nigel P; Fitzgerald, Richard J.; Smyth, Thomas J (MDPI, 2015)

Phlorotannins are a group of complex polymers of phloroglucinol (1,3,5-trihydroxybenzene) unique to macroalgae. These phenolic compounds are integral structural components of the cell wall in brown algae, but also play ...
Profiling the Diversity of Microbial Communities with Single-Strand Conformation Polymorphism (SSCP).

Schmalenberger, Achim; Tebbe, Christoph C (Humana Press, 2014)

Genetic fingerprinting techniques for microbial community analysis have evolved over the last decade into standard applications for efficient and fast differentiation of microbial communities based on their diversity. These ...
Promoting cell proliferation using water dispersible germanium nanowires.

Bezuidenhout, Michael; Liu, Pai; Singh, Shalini; Kiely, Maeve; Ryan, Kevin M.; Kiely, Patrick A (Public Library of Science, 2014)

Group IV Nanowires have strong potential for several biomedical applications. However, to date their use remains limited because many are synthesised using heavy metal seeds and functionalised using organic ligands to make ...
Prospects for the management of type 2 diabetes using food protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity

Nongonierma, Alice B; Fitzgerald, Richard J. (Elsevier, 2016)

Since drug based inhibition of dipeptidyl peptidase IV (DPP-IV) is employed in type 2 (T2D) diabetes therapy, food protein hydrolysates which inhibit DPP- IV may also have potential in the management of T2D. Specific peptide ...
Proteolytic release of angiotensin converting enzyme inhibitory peptides from food proteins.

Norris, Roseanne (University of Limerick, 2013)

The potential of an Aspergillus niger derived prolyl endoproteinase (An-PEP) to produce potent angiotensin converting enzyme (ACE) inhibitory peptides was assessed. Bovine α- and β-casein were purified from acid caseinate ...
Purification and characterization of a lysine-p-nitroanilide hydrolase, a broad specificity aminopeptidase, from the cytoplasm of Lactococcus lactis subsp. cremoris AM2

McDonnell, Maeve; Bouchier, Paul; Fitzgerald, Richard J.; O'Cuinn, Gerard (Cambridge University Press, 1999)

Summary. A hydrolase activity that cleaves lysyl-p-nitroanilide (Lys-pNA) has been purified from the cytoplasm of Lactococcus lactis subsp. cremoris AM2 by chromatography on DE52, DEAE Affi-Gel Blue Gel, Hydroxyapatite ...
Quinoa (Chenopodium quinoa Willd.) protein hydrolysates with in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory and antioxidant properties

Nongonierma, Alice B; Le Maux, Solène; Dubrulle, Cécile; Barre, Chloé; Fitzgerald, Richard J. (Elsevier, 2015)

The potential of quinoa to act as a source of dipeptidyl peptidase IV (DPP-IV) inhibitory and antioxidant peptides was studied. A quinoa protein isolate (QPI) with a purity of 40.73 ± 0.90% was prepared. The QPI was ...
RACK(1) to the future - a historical perspective

Ron, Dorit; Adams, David R; Baillie, George S; Long, Aideen; O'Connor, Rosemary; Kiely, Patrick A (BioMed Central, 2013)

This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1's role in the immune system, the heart and the brain were discussed and its ...

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