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Outcomes of implementation of the FilmArray meningoencephalitis panel in a tertiary hospital between 2017 and 2020

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dc.contributor.author Teoh, TeeKeat
dc.contributor.author Powell, James
dc.contributor.author O'Keeffe, Jillian
dc.contributor.author Donlon, Eoghan
dc.contributor.author Dillon, Lisa
dc.contributor.author Lenihan, Marie
dc.contributor.author Mostyn, Amanda
dc.contributor.author Power, Lorraine
dc.contributor.author Boers, Peter
dc.contributor.author Stapleton, Patrick J.
dc.contributor.author O'Connell, Nuala H.
dc.contributor.author Dunne, Colum P.
dc.date.accessioned 2022-04-01T08:24:36Z
dc.date.available 2022-04-01T08:24:36Z
dc.date.issued 2022
dc.identifier.uri http://hdl.handle.net/10344/11169
dc.description peer-reviewed en_US
dc.description.abstract Acute meningoencephalitis is encountered commonly in the acute hospital setting and is associated with significant morbidity and mortality, in addition to significant healthcare costs. Multiplex PCR panels now allow syndromic testing for central nervous system infection. The BioFire® FilmArray® Meningoencephalitis (ME) allows testing of 14 target pathogens using only 0.2mls of cerebrospinal fluid (CSF). We conducted a retrospective observational study to assess the performance of the assay and secondarily to observe the clinical utility of negative results by comparing clinical outcomes of aseptic meningitis to bacterial and viral meningoencepha Methods Data for CSF samples tested using the FilmArray ME panel from October 2017 to October 2020 were analysed. Detection of bacterial and viral targets was analysed. Admission to critical care area, 90-day readmission rates, average length of stay and 30-day and 90-day mortality were analysed for three groups with following diagnoses: bacterial meningitis, viral meningoencephalitis, or aseptic meningitis. en_US
dc.language.iso eng en_US
dc.publisher Public Library of Science en_US
dc.relation.ispartofseries PLoS ONE;17(3), e0265187.
dc.subject meningoencephalitis en_US
dc.subject PCR panels en_US
dc.title Outcomes of implementation of the FilmArray meningoencephalitis panel in a tertiary hospital between 2017 and 2020 en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1371/journal.pone.0265187
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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