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Relationship between parent-reported gastrointestinal symptoms, sleep problems, autism spectrum disorder symptoms, and behavior problems in children and adolescents with 22q11.2 deletion syndrome

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dc.contributor.author Leader, Geraldine
dc.contributor.author Murray, Maeve
dc.contributor.author O'Súilleabháin, Páraic S.
dc.contributor.author Maher, Leanne
dc.contributor.author Naughton, Katie
dc.contributor.author Arndt, Sophia
dc.contributor.author White, Keeley
dc.contributor.author Traina, Ivan
dc.contributor.author Mannion, Arlene
dc.date.accessioned 2021-09-29T10:12:51Z
dc.date.available 2021-09-29T10:12:51Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/10622
dc.description peer-reviewed en_US
dc.description.abstract Background: 22q11.2 deletion syndrome (22q) is a chromosome disorder, where a segment of chromosome 22, located at q11.2, is missing. This study aims to investigate the relationship between a number of parent-reported comorbid conditions including gastrointestinal symptoms, sleep problems, autism spectrum disorder (ASD) symptoms and behavior problems in children and adolescents with 22q deletion syndrome. Method: The Gastrointestinal Symptom Inventory, Children’s Sleep Habits Questionnaire, Behavior Problem Inventory-Short Form and the Social Communication Questionnaire were completed by parents of 149 children and adolescents aged 3–18 years with a diagnosis of 22q. Results: A series of correlations and hierarchical multiple regressions were conducted to examine the relationships between GI symptoms, sleep problems and behavior problems in children and adolescents with 22q deletion syndrome. A significant moderate relationship was found between GI symptoms and sleep problems. Gender and ASD symptoms predicted GI symptoms. Significant small relationships were found between GI symptoms and self-injurious behavior. Significant small to moderate relationships were found between sleep problems and self-injurious behavior, aggressive/destructive behavior, and sterotyped behavior. Sleep problems predicted challenging behavior. Conclusions: This research demonstrated the importance of studying the relationship between comorbidities, including gastrointestinal symptoms, sleep problems, and behavior problems and how they shape the phenotype of 22q deletion syndrome. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Research in Developmental Disabilities;104, 103698
dc.subject 22q11.2 deletion syndrome en_US
dc.subject comorbidity en_US
dc.subject gastrointestinal symptoms en_US
dc.subject sleep problems en_US
dc.subject behavior problems en_US
dc.title Relationship between parent-reported gastrointestinal symptoms, sleep problems, autism spectrum disorder symptoms, and behavior problems in children and adolescents with 22q11.2 deletion syndrome en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2021-09-29T10:04:12Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1016/j.ridd.2020.103698
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2973126
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Research In Developmental Disabilities
dc.description.status peer-reviewed


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