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Fish polar lipids retard atherosclerosis in rabbits by down-regulating PAF biosynthesis and up regulating PAF catabolism

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dc.contributor.author Nasopoulou, Constantina
dc.contributor.author Tsoupras, Alexandros
dc.contributor.author Karantonis, Haralabos C.
dc.contributor.author Demopoulos, Constantinos A.
dc.contributor.author Zabetakis, Ioannis
dc.date.accessioned 2021-09-20T09:56:50Z
dc.date.available 2021-09-20T09:56:50Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10344/10577
dc.description peer-reviewed en_US
dc.description.abstract Background: Platelet activating factor (PAF) has been proposed as a key factor and initial trigger in atherosclerosis. Recently, a modulation of PAF metabolism by bioactive food constituents has been suggested. In this study we investigated the effect of fish polar lipid consumption on PAF metabolism. Results: The specific activities of four PAF metabolic enzymes; in leukocytes, platelets and plasma, and PAF concentration; either in blood cells or plasma were determined. Samples were acquired at the beginning and at the end of a previously conducted study in male New Zealand white rabbits that were fed for 45 days with atherogenic diet supplemented (group-B, n = 6) or not (group-A, n = 6) with gilthead sea bream (Sparus aurata) polar lipids. The specific activity of PAF-Acetylhydrolase (PAF-AH); a catabolic enzyme of PAF, was decreased in rabbits’ platelets of both A and B groups and in rabbits’ leukocytes of group A (p < 0.05). On the other hand the specific activity of Lipoprotein-associated Phospholipase A2 (Lp-PLA2); the catabolic enzyme of PAF in plasma was increased in both A and B groups in both leukocytes and platelets (p < 0.05). PAF-cholinephosphotransferase (PAF-CPT); a biosynthetic enzyme of PAF showed increased specific activity only in rabbits’ leukocytes of group A (p < 0.05). Neither of the two groups showed any change in Lyso-PAF-acetyltransferase (Lyso-PAF-AT) specific activity (p > 0.05). Free and bound PAF levels increased in group A while decreased in group B (p < 0.05). Conclusions: Gilthead sea bream (Sparus aurata) polar lipids modulate PAF metabolism upon atherosclerotic conditions in rabbits leading to lower PAF levels and activity in blood of rabbits with reduced early atherosclerotic lesions compared to control group. en_US
dc.language.iso eng en_US
dc.publisher BMC en_US
dc.relation.ispartofseries Lipids in Health and Disease;10:213
dc.relation.uri http://dx.doi.org/:10.1186/1476-511X-10-213
dc.subject fish polar lipids en_US
dc.subject Mediterranean Diet en_US
dc.subject cholesterol en_US
dc.subject platelet activating factor (PAF) en_US
dc.subject PAF Enzymes en_US
dc.subject atherosclerosis en_US
dc.title Fish polar lipids retard atherosclerosis in rabbits by down-regulating PAF biosynthesis and up regulating PAF catabolism en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1186/1476-511X-10-213
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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