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Ethnic differences in prevalence of actionable HbA1c levels in UK biobank: implications for screening

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dc.contributor.author Anderson, Jana J.
dc.contributor.author Welsh, Paul
dc.contributor.author Ho, Frederick K
dc.contributor.author Ferguson, Lyn D
dc.contributor.author Welsh, Claire E
dc.contributor.author Pellicori, Pierpaolo
dc.contributor.author Cleland, John G F
dc.contributor.author Forbes, John F.
dc.contributor.author Iliodromiti, Stamatina
dc.contributor.author Boyle, James
dc.contributor.author Lindsay, Robert
dc.contributor.author Celis-Morales, Carlos
dc.contributor.author Gray, Stuart Robert
dc.contributor.author Katikireddi, Srinivasa Vittal
dc.contributor.author Gill, Jason Martin Regnald
dc.contributor.author Pell, Jill P.
dc.contributor.author Sattar, Naveed
dc.date.accessioned 2021-08-31T08:14:16Z
dc.date.available 2021-08-31T08:14:16Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10536
dc.description peer-reviewed en_US
dc.description.abstract Introduction Early detection and treatment of diabetes as well as its prevention help lessen longer-term complications. We determined the prevalence of pre-diabetes and undiagnosed diabetes in the UK Biobank and standardized the results to the UK general population. Research design and methods This cross-sectional study analyzed baseline UK Biobank data on plasma glycated hemoglobin (HbA1c) to compare the prevalence of pre-diabetes and undiagnosed diabetes mellitus in white, South Asian, black, and Chinese participants. The overall and ethnic-specific results were standardized to the UK general population aged 40–70 years of age. Results Within the UK Biobank, the overall crude prevalence was 3.6% for pre-diabetes, 0.8% for undiagnosed diabetes, and 4.4% for either. Following standardization to the UK general population, the results were similar at 3.8%, 0.8%, and 4.7%, respectively. Crude prevalence was much higher in South Asian (11.0% pre-diabetes; 3.6% undiagnosed diabetes; 14.6% either) or black (13.8% pre-diabetes; 3.0% undiagnosed diabetes; 16.8% either) participants. Only six middle-aged or old-aged South Asian individuals or seven black would need to be tested to identify an HbA1c result that merits action. Conclusions Single-stage population screening for pre-diabetes or undiagnosed diabetes in middle-old or old-aged South Asian and black individuals using HbA1c could be efficient and should be considered en_US
dc.language.iso eng en_US
dc.publisher BMJ Open en_US
dc.relation.ispartofseries Diabetes Research & Care;9, e002176
dc.subject diabetes en_US
dc.subject Chinese participants en_US
dc.title Ethnic differences in prevalence of actionable HbA1c levels in UK biobank: implications for screening en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1136/bmjdrc-2021-002176
dc.contributor.sponsor British Heart Foundation en_US
dc.contributor.sponsor Medical Research Council en_US
dc.contributor.sponsor Scottish Government Chief Scientist Office en_US
dc.relation.projectid RE/18/6/34217 en_US
dc.relation.projectid MC_UU_12017/13 en_US
dc.relation.projectid SPHSU13 en_US
dc.relation.projectid SCAF/15/02 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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