dc.contributor.author | Anderson, Jana J. | |
dc.contributor.author | Welsh, Paul | |
dc.contributor.author | Ho, Frederick K. | |
dc.contributor.author | Ferguson, Lyn D | |
dc.contributor.author | Welsh, Claire E. | |
dc.contributor.author | Pellicori, Pierpaolo | |
dc.contributor.author | Cleland, John G.F. | |
dc.contributor.author | Forbes, John F. | |
dc.contributor.author | Iliodromiti, Stamatina | |
dc.contributor.author | Boyle, James | |
dc.contributor.author | Lindsay, Robert | |
dc.contributor.author | Celis-Morales, Carlos A. | |
dc.contributor.author | Gray, Stuart R. | |
dc.contributor.author | Katikireddi, Srinivasa Vittal | |
dc.contributor.author | Gill, Jason M.R. | |
dc.contributor.author | Pell, Jill P. | |
dc.contributor.author | Sattar, Naveed | |
dc.date.accessioned | 2021-08-31T08:14:16Z | |
dc.date.available | 2021-08-31T08:14:16Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://hdl.handle.net/10344/10536 | |
dc.description | peer-reviewed | en_US |
dc.description.abstract | Introduction Early detection and treatment of diabetes as well as its prevention help lessen longer-term complications. We determined the prevalence of pre-diabetes and undiagnosed diabetes in the UK Biobank and standardized the results to the UK general population. Research design and methods This cross-sectional study analyzed baseline UK Biobank data on plasma glycated hemoglobin (HbA1c) to compare the prevalence of pre-diabetes and undiagnosed diabetes mellitus in white, South Asian, black, and Chinese participants. The overall and ethnic-specific results were standardized to the UK general population aged 40–70 years of age. Results Within the UK Biobank, the overall crude prevalence was 3.6% for pre-diabetes, 0.8% for undiagnosed diabetes, and 4.4% for either. Following standardization to the UK general population, the results were similar at 3.8%, 0.8%, and 4.7%, respectively. Crude prevalence was much higher in South Asian (11.0% pre-diabetes; 3.6% undiagnosed diabetes; 14.6% either) or black (13.8% pre-diabetes; 3.0% undiagnosed diabetes; 16.8% either) participants. Only six middle-aged or old-aged South Asian individuals or seven black would need to be tested to identify an HbA1c result that merits action. Conclusions Single-stage population screening for pre-diabetes or undiagnosed diabetes in middle-old or old-aged South Asian and black individuals using HbA1c could be efficient and should be considered | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BMJ Open | en_US |
dc.relation.ispartofseries | Diabetes Research & Care;9, e002176 | |
dc.subject | diabetes | en_US |
dc.subject | Chinese participants | en_US |
dc.title | Ethnic differences in prevalence of actionable HbA1c levels in UK biobank: implications for screening | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type.supercollection | all_ul_research | en_US |
dc.type.supercollection | ul_published_reviewed | en_US |
dc.identifier.doi | 10.1136/bmjdrc-2021-002176 | |
dc.contributor.sponsor | British Heart Foundation | en_US |
dc.contributor.sponsor | Medical Research Council | en_US |
dc.contributor.sponsor | Scottish Government Chief Scientist Office | en_US |
dc.relation.projectid | RE/18/6/34217 | en_US |
dc.relation.projectid | MC_UU_12017/13 | en_US |
dc.relation.projectid | SPHSU13 | en_US |
dc.relation.projectid | SCAF/15/02 | en_US |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | en_US |