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A self-powered piezo-bioelectric device regulates tendon repair-associated signaling pathways through modulation of mechanosensitive ion channels

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Show simple item record Fernandez-Yague, Marc Trotier, Alexandre Demir, Secil Abbah, Sunny Akogwu Larrañaga, Aitor Thirumaran, Arun Stapleton, Aimee Tofail, Syed A.M. Palma, Matteo Kilcoyne, Michelle Pandit, Abhay Biggs, Manus J. 2021-08-30T14:19:20Z 2021-08-30T14:19:20Z 2021
dc.description peer-reviewed en_US
dc.description.abstract Tendon disease constitutes an unmet clinical need and remains a critical challenge in the field of orthopaedic surgery. Innovative solutions are required to overcome the limitations of current tendon grafting approaches, and bioelectronic therapies show promise in treating musculoskeletal diseases, accelerating functional recovery through the activation of tissue regeneration specific signaling pathways. Self-powered bioelectronic devices, particularly piezoelectric materials, represent a paradigm shift in biomedicine, negating the need for battery or external powering and complementing existing mecha notherapy to accelerate the repair processes. Here, the dynamic response of tendon cells to a piezoelectric collagen-analogue scaffold comprised of aligned nanoscale fibers made of the ferroelectric material poly(vinylidene fluoride-co-trifluoroethylene) is shown. It is demonstrated that motion powered electromechanical stimulation of tendon tissue through piezo bioelectric device results in ion channel modulation in vitro and regulates specific tissue regeneration signaling pathways. Finally, the potential of the piezo-bioelectronic device in modulating the progression of tendinopathy associated processes in vivo, using a rat Achilles acute injury model is shown. This study indicates that electromechanical stimulation regulates mechanosensitive ion channel sensitivity and promotes tendon-specific over non-tenogenic tissue repair processes. en_US
dc.language.iso eng en_US
dc.publisher Wiley and Sons Ltd en_US
dc.relation.ispartofseries Advanced Materials;2008788
dc.subject orthopaedic surgery en_US
dc.subject musculoskeletal diseases en_US
dc.title A self-powered piezo-bioelectric device regulates tendon repair-associated signaling pathways through modulation of mechanosensitive ion channels en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1002/adma.202008788
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor Horizon 2020 en_US
dc.contributor.sponsor European Union (EU) en_US
dc.contributor.sponsor ERDF en_US
dc.relation.projectid 16/BBSRC/3317 en_US
dc.relation.projectid 898737 en_US
dc.relation.projectid 13/RC/2073 en_US
dc.relation.projectid 13/RC/2073_P2 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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