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A blood biomarker and clinical correlation cohort study protocol to diagnose sports-related concussion and monitor recovery in elite rugby

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dc.contributor.author Kearns, Jamie
dc.contributor.author Ross, Aisling M.
dc.contributor.author Walsh, Darragh R.
dc.contributor.author Cahalane, Rachel M.
dc.contributor.author Hinchion, Rita
dc.contributor.author Ryan, Maria C.
dc.contributor.author Conway, Elaine
dc.contributor.author Comyns, Thomas M.
dc.contributor.author Kenny, Ian C.
dc.contributor.author O'Connor, Eibhlís M.
dc.contributor.author McGourty, Kieran Denis
dc.contributor.author Mulvihill, John J.E.
dc.date.accessioned 2021-08-25T14:49:45Z
dc.date.available 2021-08-25T14:49:45Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/10344/10519
dc.description peer-reviewed en_US
dc.description.abstract Introduction In professional rugby, sports-related concussion (SRC) remains the most frequent time loss injury. Therefore, accurately diagnosing SRC and monitoring player recovery, through a multi-modal assessment process, is critical to SRC management. In this protocol study, we aim to assess SRC over multiple time points post-injury to determine the value of multi-modal assessments to monitor player recovery. This is of significance to minimise premature return-to-play and, ultimately, to reduce the long-term effects associated with SRC. The study will also establish the logistics of implementing such a study in a professional setting to monitor a player’s SRC recovery. Methods and analysis All players from the participating professional rugby club within the Irish Rugby Football Union are invited to participate in the current study. Player assessment includes head injury assessment (HIA), neuropsychometric assessment (ImPACT), targeted biomarker analysis and untargeted biomarker analysis. Baseline HIA, ImPACT, and blood draws are performed prior to the start of playing season. During the baseline tests, player’s complete consent forms and an SRC history questionnaire. Subsequently, any participant that enters the HIA process over the playing season due to a suspected SRC will be clinically assessed (HIA and ImPACT) and their blood will be drawn within 3 days of injury, 6 days post-injury, and 13 days post-injury. Ethics and dissemination Ethical approval was attained from the Science and Engineering Research Ethics Committee, University of Limerick (Approval Code: 2018_06_11_S&E). On completion of the study, further manuscripts will be published to present the results of the tests and their ability to measure player recovery from SRC. Trial registration number NCT04485494. en_US
dc.language.iso eng en_US
dc.publisher BMJ Publishing Group en_US
dc.relation.ispartofseries BMJ Open Sport and Exercise Medicine;1, e000948
dc.subject professional rugby en_US
dc.subject sports en_US
dc.title A blood biomarker and clinical correlation cohort study protocol to diagnose sports-related concussion and monitor recovery in elite rugby en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1136/bmjsem-2020-000948
dc.contributor.sponsor HRI en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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