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The mechanical responses of advecting cells in confined flow

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Show simple item record Connolly, Sinéad Á. Newport, David McGourty, Kieran Denis 2021-08-16T10:51:39Z 2021-08-16T10:51:39Z 2020
dc.description peer-reviewed en_US
dc.description.abstract Fluid dynamics have long influenced cells in suspension. Red blood cells and white blood cells are advected through biological microchannels in both the cardiovascular and lymphatic systems and, as a result, are subject to a wide variety of complex fluidic forces as they pass through. In vivo, microfluidic forces influence different biological processes such as the spreading of infection, cancer metastasis, and cell viability, highlighting the importance of fluid dynamics in the blood and lymphatic vessels. This suggests that in vitro devices carrying cell suspensions may influence the viability and functionality of cells. Lab-on-a-chip, flow cytometry, and cell therapies involve cell suspensions flowing through microchannels of approximately 100–800 μm. This review begins by examining the current fundamental theories and techniques behind the fluidic forces and inertial focusing acting on cells in suspension, before exploring studies that have investigated how these fluidic forces affect the reactions of suspended cells. In light of these studies’ findings, both in vivo and in vitro fluidic cell microenvironments shall also be discussed before concluding with recommendations for the field en_US
dc.language.iso eng en_US
dc.publisher American Institute of Physics en_US
dc.relation GOIPG/2016/1265 en_US
dc.relation.ispartofseries Biomicrofluidics;14, 031501
dc.subject Fluid dynamics en_US
dc.title The mechanical responses of advecting cells in confined flow en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1063/5.0005154
dc.contributor.sponsor IRC en_US
dc.relation.projectid GOIPG/2016/1265 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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