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MicroRNA and other non-coding RNAs in epstein–barr virus-associated cancers

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Show simple item record Notarte, Kin Israel Senanayake, Suranga Macaranas, Imee Albano, Pia Marie Mundo, Lucia Fennell, Eanna Leoncini, Lorenzo Murray, Paul 2021-08-13T08:56:21Z 2021-08-13T08:56:21Z 2021
dc.description peer-reviewed en_US
dc.description.abstract EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation CZ.02.1.01/0.0/0.0/16_019/0000868 en_US
dc.relation.ispartofseries Cancers;13, 3909
dc.subject microRNAome en_US
dc.subject miRNA en_US
dc.subject carcinogenesis en_US
dc.title MicroRNA and other non-coding RNAs in epstein–barr virus-associated cancers en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/cancers13153909
dc.identifier.doi 10.1016/j.spc.2021.07.017
dc.contributor.sponsor European Union (EU) en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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