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Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms

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dc.contributor.author Malijauskaite, Sigita
dc.contributor.author Connolly, Sinéad Á.
dc.contributor.author Newport, David
dc.contributor.author McGourty, Kieran Denis
dc.date.accessioned 2021-07-13T09:34:01Z
dc.date.available 2021-07-13T09:34:01Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10339
dc.description peer-reviewed en_US
dc.description.abstract Intestinal tissue, and specifically its mucosal layer, is a complex and gradient-rich environment. Gradients of soluble factor (BMP, Noggin, Notch, Hedgehog, and Wnt), insoluble extracellular matrix proteins (laminins, collagens, fibronectin, and their cognate receptors), stromal stiffness, oxygenation, and sheer stress induced by luminal fluid flow at the crypt-villus axis controls and supports healthy intestinal tissue homeostasis. However, due to current technological challenges, very few of these features have so far been included in in vitro intestinal tissue mimetic platforms. In this review, the tightly defined and dynamic microenvironment of the intestinal tissue is presented in detail. Additionally, the authors introduce the current state-of-the-art intestinal tissue mimetic platforms, as well as the design drawbacks and challenges they face while attempting to capture the complexity of the intestinal tissue’s physiology. Finally, the compositions of an “idealized” mimetic system is presented to guide future developmental efforts. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Cytokine and Growth Factor Reviews;60, pp. 76–88
dc.subject Enteroids en_US
dc.subject ASCs en_US
dc.subject ISCs en_US
dc.title Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.cytogfr.2021.03.002
dc.contributor.sponsor IRC en_US
dc.relation.projectid GOIPG/2019/3693 en_US
dc.relation.projectid GOIPG/2016/1265 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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