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Hepatic macrophage responses in inflammation, a function of plasticity, heterogeneity or both?

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Show simple item record Zwicker, Christian Christian, Anna Scott, Charlotte L. 2021-07-06T08:51:52Z 2021-07-06T08:51:52Z 2021
dc.description peer-reviewed en_US
dc.description.abstract With the increasing availability and accessibility of single cell technologies, much attention has been given to delineating the specific populations of cells present in any given tissue. In recent years, hepatic macrophage heterogeneity has also begun to be examined using these strategies. While previously any macrophage in the liver was considered to be a Kupffer cell (KC), several studies have recently revealed the presence of distinct subsets ofhepatic macrophages, including those distinct from KCs both under homeostatic and non-homeostatic conditions. This heterogeneity has brought the concept of macrophage plasticity into question. Are KCs really as plastic as once thought, being capable of responding efficiently and specifically to any given stimuli? Or are the differential responses observed from hepatic macrophages in distinct settings due to the presence of multiple subsets of these cells? With these questions in mind, here we examine what is currently understood regarding hepatic macrophage heterogeneity in mouse and human and examine the role of heterogeneity vs plasticity in regards to hepatic macrophage responses in settings of both pathogen-induced and sterile inflammation. en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation #101027317 en_US
dc.relation.ispartofseries Frontiers in Immunology;
dc.subject hepatic macrophages en_US
dc.subject Kupffer cells en_US
dc.title Hepatic macrophage responses in inflammation, a function of plasticity, heterogeneity or both? en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3389/fimmu.2021.690813
dc.contributor.sponsor Horizon 2020 (ERC) en_US
dc.relation.projectid #851908 en_US
dc.relation.projectid 3G000519 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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