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Consumption of high-leucine-containing protein bar following breakfast impacts aminoacidemia and subjective appetite in older persons

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dc.contributor.author Traylor, Daniel A.
dc.contributor.author Kamal, Michael
dc.contributor.author Nunes, Everson A
dc.contributor.author Prior, Todd
dc.contributor.author Gorissen, Stefan H.M.
dc.contributor.author Lees, Matthew J.
dc.contributor.author Gesel, Fran
dc.contributor.author Lim, Changhyun
dc.contributor.author Phillips, Stuart M.
dc.date.accessioned 2021-07-05T13:32:02Z
dc.date.available 2021-07-05T13:32:02Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10301
dc.description peer-reviewed en_US
dc.description.abstract Background: Limited data are available examining dietary interventions for optimizing protein and leucine intake to stimulate muscle protein synthesis (MPS) in older humans. Objectives: We aimed to investigate the aminoacidemia and appetite responses of older adults after consuming breakfast, a meal frequently consumed with high-carbohydrate and below-par amounts of protein and leucine for stimulating MPS. Methods: Five men and 3 women (means ± SD; age: 74 ± 7 y, BMI: 25.7 ± 4.9 kg/m2, fat- and bone-free mass: 63 ± 7 kg) took part in this experiment in which they consumed breakfasts with low-protein (LP = 13 ± 2 g), high-protein (HP = 32 ± 5 g), and LP followed by a protein- and leucine-enriched bar formulation 2 h later (LP + Bar = 29 ± 2 g). The LP, HP, and LP + Bar breakfast conditions contained 519 ± 86 kcal, 535 ± 83 kcal, and 739 ± 86 kcal, respectively. Blood samples were drawn for 6 h and analyzed for amino acid, insulin, and glucose concentrations. Visual analog scales were assessed for hunger, fullness, and desire to eat. Results: The net AUC for essential amino acid (EAA) exposure was similar between the LP + Bar and HP conditions but greater in the HP condition compared with the LP condition. Peak leucinemia was higher in the LP + Bar condition compared with the HP, and both were greater than the LP condition. Net leucine exposure was similar between HP and LP + Bar, and both were greater than LP. Hunger was similarly reduced in LP + Bar and HP, and LP + Bar resulted in a greater hunger reduction than LP. Both LP + Bar and HP resulted in greater net fullness scores than LP. Conclusions: Consuming our bar formulation increased blood leucine availability and net exposure to EAAs to a similar degree as consuming a high-protein meal. High-protein at breakfast results in a greater net exposure to EAAs and leucine, which could support MPS in older persons. This study was registered at clinicaltrials.gov as NCT03712761. en_US
dc.language.iso eng en_US
dc.publisher Oxford University Press on behalf of the American Society for Nutrition en_US
dc.relation.ispartofseries Current Developments in Nutrition;5 (6), nzab080
dc.relation.uri http://dx.doi.org/10.1093/cdn/nzab080
dc.subject aging en_US
dc.subject amino acids en_US
dc.subject dietary intervention en_US
dc.subject milk protein en_US
dc.subject muscle preservation en_US
dc.subject randomized trial en_US
dc.subject sarcopenia en_US
dc.subject satiety en_US
dc.subject supplement en_US
dc.title Consumption of high-leucine-containing protein bar following breakfast impacts aminoacidemia and subjective appetite in older persons en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1093/cdn/nzab080
dc.contributor.sponsor National Science and Engineering Research Council (NSERC) of Canada and the Canada Research en_US
dc.contributor.sponsor Brazilian National Council for Scientific and Technological Development (CNPq) en_US
dc.relation.projectid 308584/2019-8 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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