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Serotonin levels in the serum of persons with onchocerciasis-associated epilepsy: A case-control study

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Show simple item record Vieri, Melissa Krizia Hotterbeekx, An Mandro, Michel Fodjo, Joseph Nelson Siewe Dusabimana, Alfred Nyisi, Francoise Mukendi, Deby Gwatsvaira, Joe Kumar-Singh, Samir Colebunders, Robert 2021-06-25T10:09:51Z 2021-06-25T10:09:51Z 2021
dc.description peer-reviewed en_US
dc.description.abstract Onchocerciasis-associated epilepsy (OAE) is a devastating childhood disorder occurring in areas with high Onchocerca volvulus transmission. Despite epidemiological evidence showing the association between O. volvulus and epilepsy, the underlying mechanism remains unknown. Since high levels of serotonin are known to induce seizures, we investigated serotonin levels in persons with OAE and controls selected from the Democratic Republic of Congo. Serum serotonin levels were determined by ELISA in 19 persons with OAE, 32 persons with epilepsy without O. volvulus infection, 18 with O. volvulus infection but without epilepsy, and 35 with neither O. volvulus infection nor epilepsy. O. volvulus infection was diagnosed by skin snip testing and/or OV16 antibody detection. Serum serotonin levels were significantly decreased in persons with OAE compared to persons with O. volvulus infection and no epilepsy. In conclusion, an increased serotonin level is unable to explain the pathogenesis of OAE. Other hypotheses to identify the causal mechanism of OAE will need to be investigated. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Pathogens;10, 720
dc.subject epilepsy en_US
dc.subject nodding syndrome en_US
dc.subject onchocerciasis en_US
dc.title Serotonin levels in the serum of persons with onchocerciasis-associated epilepsy: A case-control study en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/pathogens10060720
dc.contributor.sponsor VLIRUOS en_US
dc.contributor.sponsor European Union (EU) en_US
dc.relation.projectid 671055 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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