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Estrogenic plants: to prevent neurodegeneration and memory loss and other symptoms in women after menopause

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dc.contributor.author Echeverria, Valentina
dc.contributor.author Echeverria, Florencia
dc.contributor.author Barreto, George E.
dc.contributor.author Echeverría, Javier
dc.contributor.author Mendoza, Cristhian
dc.date.accessioned 2021-06-23T10:31:14Z
dc.date.available 2021-06-23T10:31:14Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10269
dc.description peer-reviewed en_US
dc.description.abstract In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging. en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation.ispartofseries Frontiers in Pharmacology;644103
dc.subject estrogens en_US
dc.subject mammals en_US
dc.title Estrogenic plants: to prevent neurodegeneration and memory loss and other symptoms in women after menopause en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3389/fphar.2021.644103
dc.contributor.sponsor Universidad San Sebastian en_US
dc.contributor.sponsor ANID en_US
dc.relation.projectid FONDECYT 1190264 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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