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Biomarkers in delirium: A systematic review

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dc.contributor.author Dunne, Suzanne S.
dc.contributor.author Coffey, Calvin J.
dc.contributor.author Konje, Swiri
dc.contributor.author Gasior, Sara
dc.contributor.author Clancy, Conor C.
dc.contributor.author Gulati, Gautam
dc.contributor.author Meagher, David
dc.contributor.author Dunne, Colum P.
dc.date.accessioned 2021-06-22T07:20:19Z
dc.date.available 2021-06-22T07:20:19Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10265
dc.description peer-reviewed en_US
dc.description.abstract Background: Delirium is a common neuropsychiatric disorder associated with prolonged hospital stays, and increased morbidity and mortality. Diagnosis is frequently missed due to varying disease presentation and lack of standardized testing. We examined biomarkers as diagnostic or prognostic indicators of delirium, and provide a rational basis for future studies. Method: Systematic review of literature published between Jan 2000 and June 2019. Searches included: PubMed; Web of Science; CINAHL; EMBASE; COCHRANE and Medline. Additional studies were identified by searching bibliographies of eligible articles. Results: 2082 relevant papers were identified from all sources. Seventy-three met the inclusion criteria, all of which were observational. These assessed a range of fourteen biomarkers. All papers included were in the English language. Assessment methods varied between studies, including: DSM criteria; Confusion Assessment Method (CAM) or CAM-Intensive Care Unit (ICU). Delirium severity was measured using the Delirium Rating Scale (DRS). Delirium was secondary to post-operative dysfunction or acute medical conditions. Conclusion: Evidence does not currently support the use of any one biomarker. However, certain markers were associated with promising results and may warrant evaluation in future studies. Heterogeneity across study methods may have contributed to inconclusive results, and more clarity may arise from standardization of methods of clinical assessment. Adjusting for comorbidities may improve understanding of the pathophysiology of delirium, in particular the role of confounders such as inflammation, cognitive disorders and surgical trauma. Future research may also benefit from inclusion of other diagnostic modalities such as EEG as well as analysis of genetic or epigenetic factors. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Journal of Psychosomatic Research;147, 110530
dc.subject Delirium en_US
dc.subject Diagnosis en_US
dc.subject Biomarkers en_US
dc.subject Systematic review en_US
dc.title Biomarkers in delirium: A systematic review en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.jpsychores.2021.110530
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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