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The complex roles of efferocytosis in cancer development, metastasis, and treatment

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Show simple item record Tajbakhsh, Amir hayat, Seyed Mohammad Gheibi Movahedpour, Ahmad Savardashtaki, Amir Loveless, Reid Barreto, George E. Teng, Yong Sahebkar, Amirhossein 2021-06-11T08:16:21Z 2021-06-11T08:16:21Z 2021
dc.description peer-reviewed en_US
dc.description.abstract When tumor cells are killed by targeted therapy, radiotherapy, or chemotherapy, they trigger their primary tumor by releasing pro-inflammatory cytokines. Microenvironmental interactions can also promote tumor heterogeneity and development. In this line, several immune cells within the tumor microenvironment, including macrophages, dendritic cells, regulatory T-cells, and CD8+ and CD4+ T cells, are involved in the clearance of apoptotic tumor cells through a process called efferocytosis. Although the efficiency of apoptotic tumor cell efferocytosis is positive under physiological conditions, there are controversies regarding its usefulness in treatment-induced apoptotic tumor cells (ATCs). Efferocytosis can show the limitation of cytotoxic treatments, such as chemotherapy and radiotherapy. Since cytotoxic treatments lead to extensive cell mortality, efferocytosis, and macrophage polarization toward an M2 phenotype, the immune response may get involved in tumor recurrence and metastasis. Tumor cells can use the anti-inflammatory effect of apoptotic tumor cell efferocytosis to induce an immunosuppressive condition that is tumor-tolerant. Since M2 polarization and efferocytosis are tumor-promoting processes, the receptors on macrophages act as potential targets for cancer therapy. Moreover, researchers have shown that efferocytosis-related molecules/pathways are potential targets for cancer therapy. These include phosphatidylserine and calreticulin, Tyro3, Axl, and Mer tyrosine kinase (MerTK), receptors of tyrosine kinase, indoleamine-2,3-dioxygenase 1, annexin V, CD47, TGF-β, IL-10, and macrophage phenotype switch are combined with conventional therapy, which can be more effective in cancer treatment. Thus, we set out to investigate the advantages and disadvantages of efferocytosis in treatment-induced apoptotic tumor cells. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Biomedicine & Pharmacotherapy;140, 111776
dc.subject Efferocytosis en_US
dc.subject Cancer en_US
dc.subject Apoptosis en_US
dc.title The complex roles of efferocytosis in cancer development, metastasis, and treatment en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.biopha.2021.111776
dc.contributor.sponsor Institute of Iran en_US
dc.contributor.sponsor Biotechnology Development Council of the Islamic Republic of Iran en_US
dc.relation.projectid 37312-202-01-97 en_US
dc.relation.projectid 960206 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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