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Production and isolation of pharmaceutical drug nanoparticles

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dc.contributor.author Verma, Vivek
dc.contributor.author Ryan, Kevin M.
dc.contributor.author Padrela, Luis
dc.date.accessioned 2021-06-08T09:16:43Z
dc.date.available 2021-06-08T09:16:43Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10144
dc.description peer-reviewed en_US
dc.description.abstract Nanosizing of pharmaceutical drug particles is one of the most important drug delivery platforms approaches for the commercial development of poorly water-soluble drug molecules. Though nanosizing of drug particles has been proven to greatly enhance drugs dissolution rate and apparent solubility, nanosized materials have presented significant challenges for their formulation as solid dosage forms (e.g. tablets, capsules). This is due to the strong Van der Waals attraction forces between dry nanoparticles leading to aggregation, cohesion, and consequently poor flowability. In this review, the broad area of nanomedicines is overviewed with the primary focus on drug nanocrystals and the top-down and bottom-up methods used in their fabrication. The review also looks at how nanosuspensions of pharmaceutical drugs are generated and stabilised, followed by subsequent strategies for isolation of the nanoparticles. A perspective on the future outlook for drug nanocrystals is also presented. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Journal of Pharmaceutics;603, 120708
dc.subject Active pharmaceutical ingredients en_US
dc.subject Nanoparticles en_US
dc.subject Bioavailability en_US
dc.title Production and isolation of pharmaceutical drug nanoparticles en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 0.1016/j.ijpharm.2021.120708
dc.contributor.sponsor EI en_US
dc.contributor.sponsor SFI en_US
dc.relation.projectid CF20170754 en_US
dc.relation.projectid 12/RC/2275_P2 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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