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Optical fbre based real‑time measurements during an LDR prostate brachytherapy implant simulation: using a 3D printed anthropomorphic phantom

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dc.contributor.author Woulfe, Peter
dc.contributor.author O'Sullivan, F. J.
dc.contributor.author Byrne, L.
dc.contributor.author Doyle, A.J.
dc.contributor.author Kam, Wern
dc.contributor.author Martyn, Michael
dc.contributor.author O'Keeffe, Sinéad
dc.date.accessioned 2021-06-02T10:39:19Z
dc.date.available 2021-06-02T10:39:19Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10132
dc.description peer-reviewed en_US
dc.description.abstract An optical fibre sensor based on radioluminescence, using the scintillation material terbium doped gadolinium oxysulphide (Gd2O2S:Tb) is evaluated, using a 3D printed anthropomorphic phantom for applications in low dose-rate (LDR) prostate brachytherapy. The scintillation material is embedded in a 700 µm diameter cavity within a 1 mm plastic optical fibre that is fixed within a brachytherapy needle. The high spatial resolution dosimeter is used to measure the dose contribution from Iodine-125 (I-125) seeds. Initially, the effects of sterilisation on the sensors (1) repeatability, (2) response as a function of angle, and (3) response as a function of distance, are evaluated in a custom polymethyl methacrylate phantom. Results obtained in this study demonstrate that the output response of the sensor, pre- and post-sterilisation are within the acceptable measurement uncertainty ranging from a maximum standard deviation of 4.7% pre and 5.5% post respectively, indicating that the low temperature sterilisation process does not damage the sensor or reduce performance. Subsequently, an LDR brachytherapy plan reconstructed using the VariSeed treatment planning system, in an anthropomorphic 3D printed training phantom, was used to assess the suitability of the sensor for applications in LDR brachytherapy. This phantom was printed based on patient anatomy, with the volume and dimensions of the prostate designed to represent that of the patient. I-125 brachytherapy seeds, with an average activity of 0.410 mCi, were implanted into the prostate phantom under transrectal ultrasound guidance; following the same techniques as employed in clinical practice by an experienced radiation oncologist. This work has demonstrated that this sensor is capable of accurately identifying when radioactive I-125 sources are introduced into the prostate via a brachytherapy needle en_US
dc.language.iso eng en_US
dc.publisher Nature en_US
dc.relation.ispartofseries Scientifc Reports;11, 11160
dc.subject prostate phantom en_US
dc.subject LDR brachytherapy en_US
dc.title Optical fbre based real‑time measurements during an LDR prostate brachytherapy implant simulation: using a 3D printed anthropomorphic phantom en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1038/s41598-021-90880-6
dc.contributor.sponsor SFI en_US
dc.relation.projectid UF150618 a en_US
dc.relation.projectid 18/TIDA/6119. en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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