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Anti-Inflammatory and anti-platelet properties of lipid bioactives from apple cider by-products

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dc.contributor.author Tsoupras, Alexandros
dc.contributor.author Moran, Donal
dc.contributor.author Byrne, Thomas
dc.contributor.author Ryan, James
dc.contributor.author Barrett, Luke
dc.contributor.author Traas, Con
dc.contributor.author Zabetakis, Ioannis
dc.date.accessioned 2021-06-02T08:20:11Z
dc.date.available 2021-06-02T08:20:11Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10130
dc.description peer-reviewed en_US
dc.description.abstract The valorization of food industry by-products as sources of bioactive compounds is at the forefront of research in functional foods and nutraceuticals. This study focuses on bioactives of apple cider by-products (ACBPs) with putative cardio-protective properties. Total lipids (TLs) were extracted from ACBPs of apple varieties that are low (ACBP1), medium (ACBP2), and high (ACBP3) in tannins and were further separated into polar lipids (PLs) and neutral lipids (NLs). The functionality of these lipid extracts and of their HPLC-derived lipid fractions/PL subclasses were assessed in vitro against human platelet aggregation induced by the thrombotic and inflammatory platelet agonists platelet-activating factor (PAF) and adenosine diphosphate (ADP). The fatty acid profile of PLs and their most bioactive lipid fractions were evaluated by GC–MS analysis. The PL extracts exhibited higher specificity against the PAF-induced platelet aggregation compared to their anti-ADP effects, while TL and NL showed lower bioactivities in all ACBPs. HPLC analysis unveiled that the most bioactive PL from all ACBPs were those in PL fraction 3 containing phosphatidylcholines (PCs). PLs from all ACBPs and their PC bioactives were rich in polyunsaturated fatty acids (PUFAs) and especially in the essential omega-6 (n-6) linoleic acid (LA) and omega-3 (n-3) alpha linolenic acid (ALA), with favorably low values of the n-6/n-3 PUFA ratio, thus providing a rationale for their higher anti-inflammatory bioactivities. Within this study, highly bioactive PL compounds with strong anti-inflammatory and anti-platelet properties were identified in ACBPs, which can be potentially utilized for producing cardio-protective functional foods and/or nutraceuticals. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.relation.ispartofseries Molecules;26, 2869
dc.subject CVD en_US
dc.subject platelets en_US
dc.title Anti-Inflammatory and anti-platelet properties of lipid bioactives from apple cider by-products en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3390/molecules26102869
dc.contributor.sponsor EI en_US
dc.relation.projectid IP-2020-0926-Y en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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