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Gold enhanced hemoglobin interaction in a Fabry-Perot based optical fiber sensor for measurement of blood refractive index

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dc.contributor.author Viphavakit, Charusluk
dc.contributor.author O'Keeffe, Sinéad
dc.contributor.author Yang, Minghong
dc.contributor.author Andersson-Engels, Stefan
dc.contributor.author Lewis, Elfed
dc.date.accessioned 2021-05-31T11:24:56Z
dc.date.available 2021-05-31T11:24:56Z
dc.date.issued 2018
dc.identifier.citation Viphavakit, C,O'Keeffe, S,Yang, MH,Andersson-Engels, S,Lewis, E (2018) 'Gold Enhanced Hemoglobin Interaction in a Fabry-Perot Based Optical Fiber Sensor for Measurement of Blood Refractive Index'. Journal Of Lightwave Technology, 36 :1118-1124. en_US
dc.identifier.uri http://hdl.handle.net/10344/10124
dc.description peer-reviewed en_US
dc.description.abstract A Fabry-Perot based optical fiber sensor to measure the oxygen concentration through monitoring the change of refractive index in red blood cells is reported. The optical fiber sensor with a diameter of 220 mu m is made entirely of fused silica glass fibers, which can be integrated within standard brachytherapy seed delivery needle to be used in vivo. Isopropanol solution and pig blood are prepared to produce refractive index in the range 1.344-1.365. Gold is coated to a thickness of 100 nm at the tip of the sensor to enhance the interaction between hemoglobin and light. A fast Fourier transform algorithm is used to analyze the phase angle from the reflected output spectrum. The gold-coated sensor has up to almost ten times higher sensitivity to hemoglobin concentration in blood solutions compared to isopropanol solutions. A sensitivity of 9.82 rad/RIU with a refractive index resolution of 2.09 x 10(-3) RIU is achieved for the sensor with a 16 mu m thickness diaphragm. en_US
dc.language.iso eng en_US
dc.publisher IEEE Computer Society en_US
dc.relation.ispartofseries Journal of Lightwave Technology;36 (4), pp. 1118 - 1124
dc.relation.uri http://dx.doi.org/10.1109/JLT.2017.2782078
dc.rights © 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. en_US
dc.subject Fabry-Perot interferometer en_US
dc.subject optical fiber sensor en_US
dc.subject refractive index sensing en_US
dc.title Gold enhanced hemoglobin interaction in a Fabry-Perot based optical fiber sensor for measurement of blood refractive index en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2021-05-31T11:15:27Z
dc.identifier.doi 10.1109/JLT.2017.2782078
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2739008
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Journal Of Lightwave Technology
dc.description.status peer-reviewed


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