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Piezoelectricity of the transmembrane protein ba3 cytochrome c oxidase

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dc.contributor.author O'Donnell, Joseph
dc.contributor.author Cazade, Pierre-André
dc.contributor.author Guerin, Sarah
dc.contributor.author Djeghader, Ahmed
dc.contributor.author Ul Haq, Ehtsham
dc.contributor.author Tao, Kai
dc.contributor.author Gazit, Ehud
dc.contributor.author Fukada, Eiichi
dc.contributor.author Silien, Christophe
dc.contributor.author Soulimane, Tewfik
dc.contributor.author Thompson, Damien
dc.contributor.author Tofail, Syed A.M.
dc.date.accessioned 2021-05-31T10:24:48Z
dc.date.available 2021-05-31T10:24:48Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10123
dc.description peer-reviewed en_US
dc.description.abstract Controlling the electromechanical response of piezoelectric biological structures including tissues, peptides, and amino acids provides new applications for biocompatible, sustainable materials in electronics and medicine. Here, the piezoelectric effect is revealed in another class of biological materials, with robust longitudinal and shear piezoelectricity measured in single crystals of the transmembrane protein ba3 cytochrome c oxidase from Thermus thermophilus. The experimental findings from piezoresponse force microscopy are substantiated using a range of control measurements and molecular models. The observed longitudinal and shear piezoelectric responses of ≈2 and 8 pm V−1 respectively, are comparable to or exceed the performance of commonly used inorganic piezoelectric materials including quartz, aluminum nitride, and zinc oxide. This suggests that transmembrane proteins may provide, in addition to physiological energy transduction, technologically useful piezoelectric material derived entirely from nature. Membrane proteins could extend the range of rationally designed biopiezoelectric materials far beyond the minimalistic peptide motifs currently used in miniaturized energy harvesters, and the finding of robust piezoelectric response in a transmembrane protein also raises fundamental questions regarding the molecular evolution, activation, and role of regulatory proteins in the cellular nanomachinery, indicating that piezoelectricity might be important for fundamental physiological processes en_US
dc.language.iso eng en_US
dc.publisher Wiley en_US
dc.relation.ispartofseries Advanced Functional Materials;2100884
dc.subject functional biomaterials en_US
dc.subject materials design en_US
dc.title Piezoelectricity of the transmembrane protein ba3 cytochrome c oxidase en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1002/adfm.202100884
dc.contributor.sponsor IReL en_US
dc.contributor.sponsor IRC en_US
dc.contributor.sponsor SFI en_US
dc.relation.projectid GOIPG/2018/1161) en_US
dc.relation.projectid 15/CDA/3491 en_US
dc.relation.projectid 12/RI/2345/SOF en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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