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Spectroscopic, density functional theory, cytotoxicity and antioxidant activities of sulfasalazine and naproxen drugs combination

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dc.contributor.author Cao, Yan
dc.contributor.author Khan, Afrasyab
dc.contributor.author Soltani, Alireza
dc.contributor.author Erfani-Moghadam, Vahid
dc.contributor.author Lup, Andrew Ng Kay
dc.contributor.author Aghaei, Mehrdad
dc.contributor.author Abdolahi, Nafiseh
dc.contributor.author Khalili, Mohsen
dc.contributor.author Cordani, Marco
dc.contributor.author Balakheyli, Hanzaleh
dc.contributor.author Tavassoli, Samaneh
dc.contributor.author Albadarin, Ahmad B.
dc.date.accessioned 2021-05-26T10:38:09Z
dc.date.available 2021-05-26T10:38:09Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10113
dc.description peer-reviewed en_US
dc.description.abstract In this study, we reported preparation and characterization of a new nano product consisting of the combination of two anti-inflammatory drugs: naproxen and sulfasalazine (Sulfoxen) where both are currently used for the treatment of inflammatory disorders. The nano combination product and its structural characterization were obtained by the Fourier transform infrared (FT IR) spectroscopy, X-ray powder diffraction (XRPD), Thermogravimetric analysis (TGA) Differential scanning calorimetry (DSC), Dynamic light scattering (DLS), Atomic force microscopy (AFM), and Field emission scanning electron microscopy (FE-SEM), respectively. The hydrogen bonding between the COOH groups of naproxen (NPX) and sulfasalazine (SSZ) drugs were evaluated by the experimental and theoretical spectra. FESEM and AFM techniques represent that the most particles of Sulfoxen have a solid dense cubical or cuboidal structure and they also have size range of 50–100 nm. The objective was to prepare the nano-formulation of the Sulfoxen with improved antioxidant properties with respect to the two compounds administered separately. We have evaluated the anti-cancer effect of Sulfoxen in comparison to sulfasalazine and naproxen drugs on MCF-7 and KYSE30 cell lines. Interestingly, exposure of the zebrafishes to Sulfoxen (12.5 mM) did not exhibit lethal toxicity compared to the control groups. Therefore, Sulfoxen could contribute to more studies for the possible future clinical use. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Arabian Journal of Chemistry;14, 103190
dc.subject Anti-inflammatory drugs en_US
dc.subject Antioxidant activity en_US
dc.title Spectroscopic, density functional theory, cytotoxicity and antioxidant activities of sulfasalazine and naproxen drugs combination en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.arabjc.2021.103190
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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