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A short-term evaluation of a prototype disposable oscillating positive expiratory pressure (OPEP) device in a cohort of children with cystic fibrosis

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dc.contributor.author O'Sullivan, Kevin Jeremiah
dc.contributor.author Power, Valerie
dc.contributor.author Linnane, Barry
dc.contributor.author McGrath, Deirdre
dc.contributor.author Mulligan, Magdalena
dc.contributor.author White, Rebecca
dc.contributor.author O'Sullivan, Leonard
dc.contributor.author Dunne, Colum P.
dc.date.accessioned 2021-05-17T11:36:28Z
dc.date.available 2021-05-17T11:36:28Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10083
dc.description peer-reviewed en_US
dc.description.abstract Background: Oscillating Positive Expiratory Pressure (OPEP) devices are important adjuncts to airway clearance therapy in patients with cystic fibrosis (CF). Current devices are typically reusable and require daily, or often more frequent, cleaning to prevent risk of infection by acting as reservoirs of potentially pathogenic organisms. In response, a daily disposable OPEP device, the UL-OPEP, was developed to mitigate the risk of contamination and eliminate the burdensome need for cleaning devices. Methods: A convenience sample of 36 participants, all current OPEP device users, was recruited from a paediatric CF service. For one month, participants replaced their current OPEP device with a novel daily disposable device. Assessment included pre- and post-intervention lung function by spirometry, as well as Lung Clearance Index. Quality of life was assessed using the Cystic Fibrosis Questionnaire – Revised, while user experience was evaluated with a post-study survey. Results: 31 participants completed the study: 18 males; median age 10 years, range 4–16 years. Lung function (mean difference±SD, %FEV1=1.69±11.93; %FVC=0.58±10.04; FEV1: FVC=0.01±0.09), LCI (mean difference±SD, 0.08±1.13), six-minute walk test, and CFQ-R were unchanged post-intervention. Participant-reported experiences of the device were predominantly positive. Conclusions: The disposable OPEP device maintained patients’ lung function during short term use (≤1 month), and was the subject of positive feedback regarding functionality while reducing the risk of airway contamination associated with ineffective cleaning en_US
dc.language.iso eng en_US
dc.publisher BMC en_US
dc.relation.ispartofseries BMC Pulmonary Medicine;21, 158
dc.subject Cystic fbrosis en_US
dc.subject Oscillating positive expiratory pressure therapy en_US
dc.title A short-term evaluation of a prototype disposable oscillating positive expiratory pressure (OPEP) device in a cohort of children with cystic fibrosis en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1186/s12890-021-01525-3
dc.contributor.sponsor EI en_US
dc.contributor.sponsor European Union (EU) en_US
dc.relation.projectid CF2016–0428-P en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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