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On the association between circulating biomarkers and atherosclerotic calcification in a cohort of arterial disease participants

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dc.contributor.author Cahalane, Rachel M.
dc.contributor.author Barrett, Hilary E.
dc.contributor.author Ross, Aisling M.
dc.contributor.author Mulvihill, John J.E.
dc.contributor.author Purtill, Helen
dc.contributor.author Selvarajah, Logeswaran
dc.contributor.author O'Brien, Julie
dc.contributor.author Kavanagh, Eamon G.
dc.contributor.author Moloneye, Michael A.
dc.contributor.author Egan, Siobhan M.
dc.contributor.author Leahy, Fiona C.
dc.contributor.author Griffin, Tomás P.
dc.contributor.author Islam, M.N.
dc.contributor.author O'Shea, Paul M.
dc.contributor.author Walsh, Michael T.
dc.contributor.author O'Connor, Eibhlís M.
dc.date.accessioned 2021-05-07T14:51:23Z
dc.date.available 2021-05-07T14:51:23Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10344/10060
dc.description peer-reviewed en_US
dc.description.abstract Background and aims Atherosclerotic calcification is a powerful predictor of cardiovascular disease. This study aims to determine whether circulating levels of a local/systemic calcification inhibitor or a marker of bone formation correlate with measures of coronary or extracoronary calcification. Methods and results Clinical computed tomography (CT) was performed on 64 arterial disease participants undergoing carotid and lower extremity endarterectomy. Coronary artery calcium (CAC) scores and volumes were acquired from the CT scans (n = 42). CAC scores and volumes were used to derive CAC density scores. Micro-CT was performed on excised carotid (n = 36) and lower extremity (n = 31) plaques to quantify the volume and volume fraction of extracoronary calcification. Circulating levels of dephospho-uncarboxylated Matrix Gla Protein (dp-ucMGP), fetuin-A, carboxylated and uncarboxylated osteocalcin (ucOC) were quantified using commercial immunoassays. Carotid participant CAC density scores were moderately negatively correlated with plasma dp-ucMGP (rs = −0.592, P = 0.008). A weak negative association was found between CAC scores and %ucOC for all participants (rs = −0.335, P = 0.040). Another weak negative correlation was observed between fetuin-A and the volume of calcification within excised carotid specimens (rs = −0.366, P = 0.031). Despite substantial differences in coronary and extracoronary calcium measurements, the levels of circulating biomarkers did not vary significantly between carotid and lower extremity subgroups. Conclusion Correlations identified between circulating biomarkers and measures of coronary and extracoronary calcium were not consistent among participant subgroups. Further research is required to determine the association between circulating biomarkers, coronary and extracoronary calcium. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.subject matrix gla protein en_US
dc.subject fetuin-A en_US
dc.subject osteocalcin en_US
dc.subject diagnostic testing en_US
dc.subject computed tomography en_US
dc.subject cardiovascular disease en_US
dc.title On the association between circulating biomarkers and atherosclerotic calcification in a cohort of arterial disease participants en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.numecd.2021.02.005
dc.contributor.sponsor IRC en_US
dc.relation.projectid GOIPG/ 2016/1554 en_US
dc.relation.projectid GOIPG/2013/1309 en_US
dc.relation.projectid 1102357 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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